Detailed information of TA system TA129491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3713699..3714373
• Replicon: chromosome
• Accession: NZ_CP041791
• Organism: Mycobacterium tuberculosis strain SEA17020023P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPK19_RS17355
• Protein ID: WP_031666341.1
• Coordinates: 3713699..3714127 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPK19_RS17360
• Protein ID: WP_003417286.1
• Coordinates: 3714131..3714373 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK19_RS17330	3709521..3709922	-	402	WP_003417264.1	cytidine deaminase	-
FPK19_RS17335	3710063..3710497	+	435	WP_072460198.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPK19_RS17340	3710494..3710928	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPK19_RS17345	3711057..3712829	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPK19_RS17350	3712829..3713620	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPK19_RS17355	3713699..3714127	-	429	WP_031666341.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK19_RS17360	3714131..3714373	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPK19_RS17365	3714495..3715109	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPK19_RS17370	3715106..3715771	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPK19_RS17375	3715772..3716305	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPK19_RS17380	3716302..3716676	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPK19_RS17385	3716773..3717837	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15860.19 Da
• Isoelectric Point: 8.5264

>T129491 WP_031666341.1 NZ_CP041791:c3714127-3713699 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAYAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T129491 NZ_CP041791:c3714127-3713699 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCTATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT129491 WP_003417286.1 NZ_CP041791:c3714373-3714131 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT129491 NZ_CP041791:c3714373-3714131 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Antitoxin

• AlphaFold DB: G0TI59