Detailed information of TA system TA129465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1975562..1976022
• Replicon: chromosome
• Accession: NZ_CP041791
• Organism: Mycobacterium tuberculosis strain SEA17020023P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPK19_RS09120
• Protein ID: WP_031666240.1
• Coordinates: 1975774..1976022 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WJ30
• Locus tag: FPK19_RS09115
• Protein ID: WP_003408528.1
• Coordinates: 1975562..1975774 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK19_RS09100	1972040..1973227	-	1188	WP_003898992.1	nitrate transporter NarK	-
FPK19_RS09105	1973514..1973798	+	285	WP_193018153.1	DUF1876 domain-containing protein	-
FPK19_RS09110	1973812..1975494	-	1683	WP_003898994.1	SulP family inorganic anion transporter	-
FPK19_RS09115	1975562..1975774	+	213	WP_003408528.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FPK19_RS09120	1975774..1976022	+	249	WP_031666240.1	ribonuclease VapC34	Toxin
FPK19_RS09125	1976030..1976767	+	738	WP_003898997.1	hypothetical protein	-
FPK19_RS09130	1976861..1978561	+	1701	WP_003898998.1	serine/threonine protein kinase PknE	-
FPK19_RS09135	1978846..1979247	-	402	WP_003408538.1	hypothetical protein	-
FPK19_RS09140	1979237..1979848	-	612	WP_193018140.1	isopentenyl-diphosphate Delta-isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8856.08 Da
• Isoelectric Point: 3.9794

>T129465 WP_031666240.1 NZ_CP041791:1975774-1976022 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQQFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T129465 NZ_CP041791:1975774-1976022 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACAGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7607.80 Da
• Isoelectric Point: 9.3146

>AT129465 WP_003408528.1 NZ_CP041791:1975562-1975774 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Nucleotide

• Length: 213 bp

>AT129465 NZ_CP041791:1975562-1975774 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A829CFE8