Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3779625..3780154 Replicon chromosome
Accession NZ_CP041790
Organism Mycobacterium tuberculosis strain SEA17020024P6C4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FPK20_RS17545 Protein ID WP_031666448.1
Coordinates 3779897..3780154 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag FPK20_RS17540 Protein ID WP_003417757.1
Coordinates 3779625..3779900 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK20_RS17520 3776423..3777860 - 1438 Protein_3460 FAD-binding oxidoreductase -
FPK20_RS17525 3777963..3778352 + 390 WP_003417745.1 DUF732 domain-containing protein -
FPK20_RS17530 3778366..3778659 - 294 WP_003417749.1 DUF3017 domain-containing protein -
FPK20_RS17535 3778656..3779501 - 846 WP_003905054.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
FPK20_RS17540 3779625..3779900 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
FPK20_RS17545 3779897..3780154 + 258 WP_031666448.1 Txe/YoeB family addiction module toxin Toxin
FPK20_RS17550 3780196..3781386 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
FPK20_RS17555 3781503..3781871 + 369 WP_003417765.1 FHA domain-containing protein -
FPK20_RS17560 3781868..3782419 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
FPK20_RS17565 3782426..3783007 - 582 WP_003417769.1 ATP/GTP-binding protein -
FPK20_RS17570 3782988..3783356 - 369 WP_003417772.1 DUF742 domain-containing protein -
FPK20_RS17575 3783334..3783726 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10100.33 Da        Isoelectric Point: 5.7047

>T129432 WP_031666448.1 NZ_CP041790:3779897-3780154 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARWITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T129432 NZ_CP041790:3779897-3780154 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTTG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT129432 WP_003417757.1 NZ_CP041790:3779625-3779900 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT129432 NZ_CP041790:3779625-3779900 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References