Detailed information of TA system TA129376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 368743..369269
• Replicon: chromosome
• Accession: NZ_CP041790
• Organism: Mycobacterium tuberculosis strain SEA17020024P6C4

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: FPK20_RS01600
• Protein ID: WP_003401560.1
• Coordinates: 368967..369269 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: FPK20_RS01595
• Protein ID: WP_003401555.1
• Coordinates: 368743..368970 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK20_RS01580	364391..365194	-	804	WP_003401540.1	hypothetical protein	-
FPK20_RS01585	365204..366601	-	1398	WP_003401544.1	sulfatase	-
FPK20_RS01590	366780..368600	+	1821	WP_031653699.1	PE family protein	-
FPK20_RS01595	368743..368970	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
FPK20_RS01600	368967..369269	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
FPK20_RS01605	369317..369538	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
FPK20_RS01610	369535..369960	+	426	WP_003401566.1	PIN domain nuclease	-
FPK20_RS01615	370096..370726	+	631	Protein_319	TetR/AcrR family transcriptional regulator	-
FPK20_RS01620	370723..371631	+	909	WP_003900117.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T129376 WP_003401560.1 NZ_CP041790:368967-369269 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T129376 NZ_CP041790:368967-369269 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT129376 WP_003401555.1 NZ_CP041790:368743-368970 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT129376 NZ_CP041790:368743-368970 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1