Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3106379..3106949 Replicon chromosome
Accession NZ_CP041789
Organism Mycobacterium tuberculosis strain SEA17020028P6C4

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag FPK21_RS14650 Protein ID WP_003414166.1
Coordinates 3106379..3106735 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag FPK21_RS14655 Protein ID WP_003901465.1
Coordinates 3106719..3106949 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK21_RS14630 3101831..3103519 - 1689 WP_003414155.1 alpha/beta hydrolase family protein -
FPK21_RS14635 3103523..3103849 - 327 WP_003414157.1 hypothetical protein -
FPK21_RS14640 3104022..3104609 + 588 WP_003914429.1 DUF3558 family protein -
FPK21_RS14645 3104628..3106277 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
FPK21_RS14650 3106379..3106735 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
FPK21_RS14655 3106719..3106949 - 231 WP_003901465.1 antitoxin MazE Antitoxin
FPK21_RS14660 3106992..3108035 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
FPK21_RS14665 3108226..3108501 + 276 WP_003911993.1 DUF1778 domain-containing protein -
FPK21_RS14670 3108677..3108931 - 255 WP_003917684.1 hypothetical protein -
FPK21_RS14675 3109079..3109483 + 405 WP_003414181.1 hypothetical protein -
FPK21_RS14680 3109480..3109671 + 192 WP_003414184.1 hypothetical protein -
FPK21_RS14685 3109735..3111024 + 1290 Protein_2898 transposase family protein -
FPK21_RS14690 3111258..3111515 + 258 WP_003899489.1 hypothetical protein -
FPK21_RS14695 3111620..3111931 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T129365 WP_003414166.1 NZ_CP041789:c3106735-3106379 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T129365 NZ_CP041789:c3106735-3106379 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT129365 WP_003901465.1 NZ_CP041789:c3106949-3106719 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT129365 NZ_CP041789:c3106949-3106719 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References