Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2225466..2226364 Replicon chromosome
Accession NZ_CP041789
Organism Mycobacterium tuberculosis strain SEA17020028P6C4

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FPK21_RS10335 Protein ID WP_003410001.1
Coordinates 2225466..2226026 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FPK21_RS10340 Protein ID WP_003410003.1
Coordinates 2226023..2226364 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK21_RS10305 2220635..2221288 - 654 WP_003409976.1 cutinase Cfp21 -
FPK21_RS10310 2221403..2221633 + 231 WP_003409980.1 DUF167 domain-containing protein -
FPK21_RS10315 2221718..2222629 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FPK21_RS10320 2222738..2223337 + 600 WP_003910883.1 L-lysine exporter -
FPK21_RS10325 2223753..2224181 + 429 WP_003409992.1 cellulose-binding protein -
FPK21_RS10330 2224407..2224946 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FPK21_RS10335 2225466..2226026 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FPK21_RS10340 2226023..2226364 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FPK21_RS10345 2226450..2226707 + 258 WP_003410006.1 hypothetical protein -
FPK21_RS10350 2226608..2226943 - 336 WP_003410009.1 dehydrogenase -
FPK21_RS10355 2227032..2227376 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FPK21_RS10360 2227370..2227618 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FPK21_RS10365 2227718..2230033 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FPK21_RS10370 2230030..2230302 - 273 WP_003410017.1 DUF1490 family protein -
FPK21_RS10375 2230355..2230711 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T129349 WP_003410001.1 NZ_CP041789:c2226026-2225466 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T129349 NZ_CP041789:c2226026-2225466 [Mycobacterium tuberculosis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT129349 WP_003410003.1 NZ_CP041789:c2226364-2226023 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT129349 NZ_CP041789:c2226364-2226023 [Mycobacterium tuberculosis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References