Detailed information of TA system TA129337

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384181..1384869
• Replicon: chromosome
• Accession: NZ_CP041789
• Organism: Mycobacterium tuberculosis strain SEA17020028P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: FPK21_RS06510
• Protein ID: WP_003406304.1
• Coordinates: 1384438..1384869 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: FPK21_RS06505
• Protein ID: WP_003406302.1
• Coordinates: 1384181..1384441 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK21_RS06485	1379758..1380582	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
FPK21_RS06490	1380587..1381768	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
FPK21_RS06495	1381845..1382945	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
FPK21_RS06500	1383116..1384105	+	990	WP_003406301.1	malate dehydrogenase	-
FPK21_RS06505	1384181..1384441	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
FPK21_RS06510	1384438..1384869	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK21_RS06515	1384892..1386475	-	1584	WP_009940130.1	PE family protein	-
FPK21_RS06520	1386655..1387515	+	861	WP_003900301.1	hypothetical protein	-
FPK21_RS06525	1387596..1388426	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FPK21_RS06530	1388483..1388776	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
FPK21_RS06535	1388773..1389042	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T129337 WP_003406304.1 NZ_CP041789:1384438-1384869 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T129337 NZ_CP041789:1384438-1384869 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT129337 WP_003406302.1 NZ_CP041789:1384181-1384441 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT129337 NZ_CP041789:1384181-1384441 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6