Detailed information of TA system TA129311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3710544..3711218
• Replicon: chromosome
• Accession: NZ_CP041788
• Organism: Mycobacterium tuberculosis strain SEA17020030P6C4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FPK22_RS17375
• Protein ID: WP_003417282.1
• Coordinates: 3710544..3710972 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FPK22_RS17380
• Protein ID: WP_003417286.1
• Coordinates: 3710976..3711218 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPK22_RS17350	3706366..3706767	-	402	WP_003417264.1	cytidine deaminase	-
FPK22_RS17355	3706908..3707342	+	435	WP_003900017.1	succinate dehydrogenase, cytochrome b556 subunit	-
FPK22_RS17360	3707339..3707773	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FPK22_RS17365	3707902..3709674	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FPK22_RS17370	3709674..3710465	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FPK22_RS17375	3710544..3710972	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPK22_RS17380	3710976..3711218	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FPK22_RS17385	3711340..3711954	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FPK22_RS17390	3711951..3712616	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FPK22_RS17395	3712617..3713150	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FPK22_RS17400	3713147..3713521	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FPK22_RS17405	3713618..3714682	-	1065	WP_003913037.1	GTP 3',8-cyclase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T129311 WP_003417282.1 NZ_CP041788:c3710972-3710544 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T129311 NZ_CP041788:c3710972-3710544 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT129311 WP_003417286.1 NZ_CP041788:c3711218-3710976 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT129311 NZ_CP041788:c3711218-3710976 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59