129281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1691004..1691620 Replicon chromosome
Accession NZ_CP041788
Organism Mycobacterium tuberculosis strain SEA17020030P6C4

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag FPK22_RS07845 Protein ID WP_003407593.1
Coordinates 1691303..1691620 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FPK22_RS07840 Protein ID WP_050174931.1
Coordinates 1691004..1691306 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK22_RS07830 1686890..1688737 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
FPK22_RS07835 1688738..1690990 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
FPK22_RS07840 1691004..1691306 + 303 WP_050174931.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
FPK22_RS07845 1691303..1691620 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
FPK22_RS07850 1691617..1692621 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
FPK22_RS07855 1692674..1693963 + 1290 WP_003407599.1 serine hydrolase -
FPK22_RS07860 1694036..1694809 - 774 WP_102770481.1 class I SAM-dependent methyltransferase -
FPK22_RS07865 1694867..1695079 - 213 WP_003898900.1 dodecin family protein -
FPK22_RS07870 1695089..1695313 - 225 WP_160522526.1 NUDIX domain-containing protein -
FPK22_RS07875 1695583..1696611 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T129281 WP_003407593.1 NZ_CP041788:1691303-1691620 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T129281 NZ_CP041788:1691303-1691620 [Mycobacterium tuberculosis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11120.38 Da        Isoelectric Point: 8.0518

>AT129281 WP_050174931.1 NZ_CP041788:1691004-1691306 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTCQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT129281 NZ_CP041788:1691004-1691306 [Mycobacterium tuberculosis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TTGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure

References