129259

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 644724..645352 Replicon chromosome
Accession NZ_CP041788
Organism Mycobacterium tuberculosis strain SEA17020030P6C4

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag FPK22_RS02885 Protein ID WP_003898500.1
Coordinates 644724..645137 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8BHC0
Locus tag FPK22_RS02890 Protein ID WP_003898501.1
Coordinates 645134..645352 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK22_RS02855 640069..640371 - 303 WP_003402896.1 DUF3349 domain-containing protein -
FPK22_RS02860 640431..640709 - 279 WP_003402901.1 hypothetical protein -
FPK22_RS02865 640706..641959 - 1254 WP_003402904.1 inorganic phosphate transporter family protein -
FPK22_RS02870 642079..642465 - 387 WP_003402907.1 VOC family protein -
FPK22_RS02875 642528..643412 - 885 WP_003402909.1 SDR family oxidoreductase -
FPK22_RS02880 643508..644410 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
FPK22_RS02885 644724..645137 - 414 WP_003898500.1 PIN domain-containing protein Toxin
FPK22_RS02890 645134..645352 - 219 WP_003898501.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
FPK22_RS02895 645587..647302 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
FPK22_RS02900 647380..648984 + 1605 WP_003402920.1 amidohydrolase -
FPK22_RS02905 648981..649961 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(3-45)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T129259 WP_003898500.1 NZ_CP041788:c645137-644724 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T129259 NZ_CP041788:c645137-644724 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7738.50 Da        Isoelectric Point: 4.1677

>AT129259 WP_003898501.1 NZ_CP041788:c645352-645134 [Mycobacterium tuberculosis]
MARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAIDAARDEFEA

Download         Length: 219 bp

>AT129259 NZ_CP041788:c645352-645134 [Mycobacterium tuberculosis]
ATGGCTCGGTTGAACGTGTATGTGCCCGACGAATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGAC
TCAGGCCGCGATCAGTGCCGAGTTGGAGAACTCCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCG
CTCGGCATGATGACGTGCTGGGTGCGATCGATGCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8BHC0

References