Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 9557..10146 Replicon plasmid unnamed1
Accession NZ_CP041782
Organism Xanthomonas citri pv. glycines strain 8ra

Toxin (Protein)


Gene name pemK Uniprot ID Q32X98
Locus tag FPK90_RS24365 Protein ID WP_012477455.1
Coordinates 9814..10146 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID Q32X99
Locus tag FPK90_RS24360 Protein ID WP_012477454.1
Coordinates 9557..9814 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK90_RS24330 5282..6202 - 921 WP_012477431.1 RepA -
FPK90_RS24335 6268..7074 - 807 WP_016851361.1 serine protease -
FPK90_RS24980 7071..7229 - 159 WP_154666355.1 hypothetical protein -
FPK90_RS24340 7452..7706 - 255 WP_012477434.1 hypothetical protein -
FPK90_RS24345 7706..8356 - 651 WP_012477435.1 ParA family protein -
FPK90_RS24350 8423..9067 - 645 WP_012477436.1 recombinase family protein -
FPK90_RS24355 9064..9291 - 228 WP_012477437.1 hypothetical protein -
FPK90_RS24360 9557..9814 + 258 WP_012477454.1 plasmid stable inheritance protein I Antitoxin
FPK90_RS24365 9814..10146 + 333 WP_012477455.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FPK90_RS24370 10235..11053 - 819 WP_012477456.1 hypothetical protein -
FPK90_RS24375 11081..13258 - 2178 WP_012477457.1 relaxase/mobilization nuclease domain-containing protein -
FPK90_RS24380 13260..13562 - 303 WP_012477458.1 hypothetical protein -
FPK90_RS24385 13850..14269 + 420 WP_012477459.1 hypothetical protein -
FPK90_RS24390 14259..14963 + 705 WP_007975110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..62666 62666


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11581.24 Da        Isoelectric Point: 9.1684

>T129249 WP_012477455.1 NZ_CP041782:9814-10146 [Xanthomonas citri pv. glycines]
MERGDIYLVSLDPTSGHEQQGTRPVLIVSPGPFNRLTKTPVVLPITTGGNFARTAGFTVSLTGGGTKTTGVVRCDQPRAL
DIGSRNGRKLESVSAAITDEVMAKLATILE

Download         Length: 333 bp

>T129249 NZ_CP041782:9814-10146 [Xanthomonas citri pv. glycines]
ATGGAGCGGGGTGATATCTATCTTGTGTCTCTCGATCCTACTTCCGGCCATGAGCAACAGGGCACTCGCCCGGTCCTGAT
TGTGTCGCCGGGACCGTTCAACCGCCTTACCAAAACACCCGTGGTGCTACCGATCACCACGGGTGGCAATTTCGCCCGTA
CGGCAGGTTTCACGGTATCCCTCACGGGGGGAGGCACCAAAACGACCGGAGTCGTGCGCTGCGATCAACCGCGCGCCCTG
GACATTGGATCGCGTAACGGCCGCAAGCTGGAAAGCGTCTCAGCAGCGATCACCGATGAGGTGATGGCTAAGCTGGCGAC
CATACTTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8951.34 Da        Isoelectric Point: 5.5491

>AT129249 WP_012477454.1 NZ_CP041782:9557-9814 [Xanthomonas citri pv. glycines]
MHTTNLRKVGGSVMLAVPPALLDVLHIGAGAKVGLAVDNGRLVVEPHARPRYTLADLLAQCDASAELASEDREWLDAKPV
GGELL

Download         Length: 258 bp

>AT129249 NZ_CP041782:9557-9814 [Xanthomonas citri pv. glycines]
ATGCACACGACAAATCTGCGCAAGGTTGGCGGTTCGGTCATGCTCGCGGTTCCGCCTGCGCTGCTCGATGTGCTGCACAT
CGGGGCAGGGGCAAAAGTGGGCTTGGCTGTCGATAACGGCCGCTTGGTAGTCGAGCCACATGCGCGCCCGCGCTACACCC
TCGCCGACCTGCTCGCCCAATGCGATGCGTCAGCCGAGCTGGCTTCCGAAGATCGGGAATGGCTTGACGCCAAGCCTGTT
GGCGGCGAGCTGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z6Z9Y5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D9EPT3

References