Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 58721..59529 Replicon plasmid unnamed1
Accession NZ_CP041780
Organism Burkholderia sp. MS455

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag FPJ27_RS35600 Protein ID WP_204426459.1
Coordinates 59023..59529 (+) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag FPJ27_RS35595 Protein ID WP_204426458.1
Coordinates 58721..59026 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ27_RS35585 55477..56514 + 1038 WP_060715300.1 ATP-binding protein -
FPJ27_RS35590 56507..58369 + 1863 WP_204426457.1 hypothetical protein -
FPJ27_RS35595 58721..59026 + 306 WP_204426458.1 DUF1778 domain-containing protein Antitoxin
FPJ27_RS35600 59023..59529 + 507 WP_204426459.1 GNAT family N-acetyltransferase Toxin
FPJ27_RS35605 59542..59802 + 261 WP_204426460.1 hypothetical protein -
FPJ27_RS35610 60189..60932 + 744 WP_204426461.1 hypothetical protein -
FPJ27_RS35615 61008..61163 + 156 WP_204426462.1 hypothetical protein -
FPJ27_RS35620 61166..61594 + 429 WP_204426463.1 hypothetical protein -
FPJ27_RS35625 61598..63445 + 1848 WP_204426464.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..197398 197398
- flank IS/Tn - - 64163..65488 1325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18048.81 Da        Isoelectric Point: 9.7622

>T129245 WP_204426459.1 NZ_CP041780:59023-59529 [Burkholderia sp. MS455]
MTLRAPTPITPEHAQAGALVAFDSGEPSLDDWLKRRALRNHANGGSRTFVVCDDQRVVAYYALASGAVDVAAAPGRFRRN
MPDPVPVVVLARLAVDRVWQGHGLGRALVRDAGLRVMQAADTIGIRGLLAHALSADAQRFYLQVGFEPSPLNPMTVMITL
ADLRAALT

Download         Length: 507 bp

>T129245 NZ_CP041780:59023-59529 [Burkholderia sp. MS455]
ATGACATTGCGCGCACCCACACCGATTACGCCGGAACACGCGCAGGCCGGGGCGTTGGTAGCCTTCGACTCGGGGGAACC
GAGCCTGGACGACTGGCTCAAGCGACGGGCGCTGCGCAATCACGCGAACGGTGGGTCGCGTACCTTCGTGGTCTGTGACG
ACCAGCGCGTCGTCGCGTACTACGCGCTCGCGTCCGGTGCGGTGGATGTCGCGGCCGCGCCCGGACGGTTTCGCCGCAAC
ATGCCGGACCCGGTGCCGGTGGTGGTGCTCGCCCGGCTCGCGGTGGACCGTGTCTGGCAAGGGCACGGGCTGGGCCGAGC
TCTGGTGCGCGACGCGGGACTGCGCGTGATGCAGGCAGCCGACACCATCGGGATTCGTGGGTTGCTTGCGCATGCGCTGT
CGGCCGACGCGCAGCGCTTCTATCTGCAGGTGGGGTTTGAGCCATCACCGCTGAATCCGATGACGGTCATGATTACGCTG
GCCGACTTGCGTGCGGCGTTGACATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10919.40 Da        Isoelectric Point: 8.7714

>AT129245 WP_204426458.1 NZ_CP041780:58721-59026 [Burkholderia sp. MS455]
MSATHSPPTKRDTLNLRVQPDERELIDRAAAARGQNRTDFILAAARAAAEETLLEATLVRARPEVYAAFVARLEAPPAPN
PPLRRTMQTPAPWDGPAGPVA

Download         Length: 306 bp

>AT129245 NZ_CP041780:58721-59026 [Burkholderia sp. MS455]
ATGTCCGCGACCCACAGCCCCCCGACCAAGCGCGACACCCTGAACCTGCGCGTGCAACCCGACGAACGTGAGCTGATCGA
TCGTGCCGCTGCCGCGCGCGGGCAGAACCGCACCGACTTCATTCTGGCCGCCGCACGGGCCGCTGCTGAGGAGACGCTGC
TCGAAGCCACGCTGGTGCGCGCCCGTCCCGAGGTCTATGCCGCGTTCGTCGCGCGGCTCGAGGCGCCGCCGGCGCCCAAT
CCCCCGTTGCGGCGCACGATGCAGACGCCCGCCCCCTGGGACGGCCCCGCGGGACCGGTTGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References