Detailed information of TA system TA129244

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 52347..52996
• Replicon: plasmid unnamed1
• Accession: NZ_CP041780
• Organism: Burkholderia sp. MS455

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ27_RS35570
• Protein ID: WP_204426455.1
• Coordinates: 52586..52996 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPJ27_RS35565
• Protein ID: WP_204426454.1
• Coordinates: 52347..52589 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ27_RS35535	48427..49395	+	969	WP_204426448.1	ParB/RepB/Spo0J family partition protein	-
FPJ27_RS35540	50046..50507	-	462	WP_204426449.1	hypothetical protein	-
FPJ27_RS35545	50523..50774	-	252	WP_204426450.1	hypothetical protein	-
FPJ27_RS35550	51030..51275	+	246	WP_204426451.1	type II toxin-antitoxin system ParD family antitoxin	-
FPJ27_RS35555	51265..51564	+	300	WP_204426452.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FPJ27_RS35560	51936..52250	+	315	WP_204426453.1	hypothetical protein	-
FPJ27_RS35565	52347..52589	+	243	WP_204426454.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FPJ27_RS35570	52586..52996	+	411	WP_204426455.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ27_RS35575	53070..53270	+	201	WP_204426456.1	hypothetical protein	-
FPJ27_RS35580	53486..53785	+	300	Protein_25	hypothetical protein	-
FPJ27_RS35585	55477..56514	+	1038	WP_060715300.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..197398	197398

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

• SpoVT-AbrB domain (12-50)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14837.15 Da
• Isoelectric Point: 6.4495

>T129244 WP_204426455.1 NZ_CP041780:52586-52996 [Burkholderia sp. MS455]
MTLYLLDTNILSNVIRDPRGACATRIGQTPPEHMCTSIIVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRADLEKQGQLIGANDMLIAAHALAVDAVLITDNTAEFTRVAGLPVENWLRPAT

Nucleotide

• Length: 411 bp

>T129244 NZ_CP041780:52586-52996 [Burkholderia sp. MS455]
ATGACGCTGTATCTGCTCGACACCAACATCTTGTCGAACGTGATCCGCGACCCGCGTGGCGCCTGCGCCACCCGCATCGG
GCAAACACCGCCCGAACACATGTGCACCTCGATCATCGTGGCGGCGGAGTTGCGATTTGGCGTCTGGAAGCGTGGCTCGT
CCACCCTCGCGCAGCGGGTCGAGCAACTGCTCGCGAGCTTGACTGTGTTGCCGTTGCAGCCCGACGCCGACCGGTGCTAC
GGCCGGTTGCGGGCCGACCTCGAGAAGCAAGGCCAACTGATTGGGGCCAACGATATGCTGATCGCCGCGCACGCGCTGGC
GGTCGACGCCGTCCTGATCACGGACAATACGGCTGAATTTACCCGTGTCGCCGGCCTGCCGGTCGAAAACTGGTTGCGGC
CGGCGACCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9242.49 Da
• Isoelectric Point: 4.6510

>AT129244 WP_204426454.1 NZ_CP041780:52347-52589 [Burkholderia sp. MS455]
MPTPDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDETFPDIDSLPAEPVDIE

Nucleotide

• Length: 243 bp

>AT129244 NZ_CP041780:52347-52589 [Burkholderia sp. MS455]
ATGCCAACACCTGACACCCGCCATGCGCGCCTGTTCCGCAATGGGCGCAGCCAGGCCGTGCGGATCCCGCGTGAGTTCGA
GCTGCCGGTTTCGGAAGTCACCATCCACCGGGAAGGCCGGCGCTTGATCATCGAGCCCGTGGAGGCCGCGCCGTTGCGTG
AGCTGTTCGCCCAATGGACTCCGCTGGACGAAACGTTTCCCGACATCGATAGCCTGCCGGCTGAACCGGTCGACATCGAA
TGA