Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1770806..1771482 Replicon chromosome
Accession NZ_CP041779
Organism Burkholderia sp. MS455

Toxin (Protein)


Gene name vagD Uniprot ID A0A0J5X1U9
Locus tag FPJ27_RS27260 Protein ID WP_027787436.1
Coordinates 1771066..1771482 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1K1RQE9
Locus tag FPJ27_RS27255 Protein ID WP_047901212.1
Coordinates 1770806..1771069 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ27_RS27240 1766360..1768612 + 2253 WP_204426324.1 TonB-dependent siderophore receptor -
FPJ27_RS27245 1768700..1769539 + 840 WP_072441434.1 N(5)-hydroxyornithine transformylase PvdF -
FPJ27_RS27250 1769539..1770555 + 1017 WP_204423269.1 acetyltransferase -
FPJ27_RS27255 1770806..1771069 + 264 WP_047901212.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FPJ27_RS27260 1771066..1771482 + 417 WP_027787436.1 PIN domain-containing protein Toxin
FPJ27_RS27265 1771531..1772436 - 906 WP_204423272.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FPJ27_RS27270 1772405..1773478 - 1074 WP_204426358.1 hypothetical protein -
FPJ27_RS27275 1773821..1774984 + 1164 WP_204423274.1 amidohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14536.66 Da        Isoelectric Point: 7.8895

>T129242 WP_027787436.1 NZ_CP041779:1771066-1771482 [Burkholderia sp. MS455]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T129242 NZ_CP041779:1771066-1771482 [Burkholderia sp. MS455]
GTGACCACGCTCTACATGCTCGATACGAACATTTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCCCGGTT
GCAGTCGTGCGTCAACGCTCAGCACCGGATCGTCGTGTCGGCAATCACCTATGCCGAAATGCGGTTCGGGGCCGTGGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCGTTTGTTTCGCGGCTGGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGACGCAACGGCCGCGATTCGCGCGGATCTCGCCGCGCGCGGCACGCCGATCGGCGCGAACGATGCGTCGATCGC
TGGGCACGCGATCGCGGCCGGCGCGGTGCTCGTCACGAACAACGGCCGCGAATTCGGCCGTGTTGCCGGGTTGTCGCTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9716.97 Da        Isoelectric Point: 4.6437

>AT129242 WP_047901212.1 NZ_CP041779:1770806-1771069 [Burkholderia sp. MS455]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFANEPLADADFLAERPAVIESGRFDLSGDAG
APTESGR

Download         Length: 264 bp

>AT129242 NZ_CP041779:1770806-1771069 [Burkholderia sp. MS455]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGTATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGCTGCTGCTGCGCCCCGTGCGCCCCACGTGGCTGTCGTTCGCGAACGAAC
CGCTGGCCGACGCCGACTTCCTCGCCGAACGCCCGGCCGTCATCGAATCCGGTCGCTTCGACCTGTCCGGCGATGCCGGC
GCGCCGACGGAGTCCGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5X1U9

Antitoxin

Source ID Structure
AlphaFold DB A0A1K1RQE9

References