Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 181485..182122 Replicon chromosome
Accession NZ_CP041779
Organism Burkholderia sp. MS455

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPJ27_RS19915 Protein ID WP_204425339.1
Coordinates 181721..182122 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FPJ27_RS19910 Protein ID WP_204425338.1
Coordinates 181485..181721 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ27_RS19890 177405..178499 - 1095 WP_204425333.1 ADP-heptose--LPS heptosyltransferase -
FPJ27_RS19895 178496..180199 - 1704 WP_204425335.1 thiamine pyrophosphate-binding protein -
FPJ27_RS19900 180490..180951 + 462 WP_072445304.1 hypothetical protein -
FPJ27_RS19905 180948..181232 + 285 WP_072445305.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
FPJ27_RS19910 181485..181721 + 237 WP_204425338.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FPJ27_RS19915 181721..182122 + 402 WP_204425339.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ27_RS19920 182189..183577 - 1389 WP_072445307.1 L-serine ammonia-lyase -
FPJ27_RS19925 183609..184745 - 1137 WP_072445308.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14955.13 Da        Isoelectric Point: 5.7368

>T129241 WP_204425339.1 NZ_CP041779:181721-182122 [Burkholderia sp. MS455]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERRNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFASYPGLRMENWLTN

Download         Length: 402 bp

>T129241 NZ_CP041779:181721-182122 [Burkholderia sp. MS455]
ATGCCGCGCTATATGCTCGACACCAACATGTGCATCTATCTGATGAAGAATCAGCCGGAGCAGGTCGCAAGACGATTCGC
GCAATGCTACACAGGGGACGTCGTGATGTCGGCGATCACGTATGCCGAACTCGAGTACGGCGTCGCTGCGTGTGCGAGTC
CTGCACGGGAGCGCCGCAATCTTGCCGCGCTGATCGACGATATTCCCGTTGCGCCGTTCGACGTCGCGGCTGCGCAAGCG
TACGGTCCTGTCCGTGAAGCAACCCGCGAGCGGAAGAAGGATCATCTCGACAAACTGATCGCGGCTCATGCCGTGTCGCT
CGATGTCGTCCTCGTGACCAACAACGAGCGGGATTTTGCGAGCTATCCGGGGTTGCGGATGGAAAACTGGCTCACCAATT
AG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9029.15 Da        Isoelectric Point: 5.8835

>AT129241 WP_204425338.1 NZ_CP041779:181485-181721 [Burkholderia sp. MS455]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPTRRPLARVLEKFAKFGPDFMSEGRGDQEQAEREGL

Download         Length: 237 bp

>AT129241 NZ_CP041779:181485-181721 [Burkholderia sp. MS455]
ATGCATACCACCAGGGTATTTCGGAACGGCAACTCGCAGGCCGTACGGATTCCAGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATCGAGCGAGTGGGTGACGAAATCCGTATTCGGCCTACGCGGCGGCCTCTGGCACGAGTGCTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGTCCGAAGGACGCGGCGATCAGGAGCAGGCTGAGCGCGAGGGTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References