Detailed information of TA system TA129239

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2535810..2537028
• Replicon: chromosome
• Accession: NZ_CP041778
• Organism: Burkholderia sp. MS455

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ27_RS15695
• Protein ID: WP_204421731.1
• Coordinates: 2536447..2537028 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1K1RWE7
• Locus tag: FPJ27_RS15690
• Protein ID: WP_072441793.1
• Coordinates: 2535810..2536367 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ27_RS15670	2531679..2532410	-	732	WP_204421727.1	ribonuclease T2	-
FPJ27_RS15675	2532663..2533241	-	579	WP_204421728.1	hypothetical protein	-
FPJ27_RS15680	2533340..2534743	-	1404	WP_204421729.1	DUF308 domain-containing protein	-
FPJ27_RS15685	2535086..2535724	+	639	WP_204421730.1	hypothetical protein	-
FPJ27_RS15690	2535810..2536367	+	558	WP_072441793.1	helix-turn-helix domain-containing protein	Antitoxin
FPJ27_RS15695	2536447..2537028	+	582	WP_204421731.1	HD domain-containing protein	Toxin
FPJ27_RS15700	2537025..2537198	+	174	Protein_2260	SAM-dependent methyltransferase	-
FPJ27_RS15705	2537474..2538667	+	1194	WP_204421732.1	efflux RND transporter periplasmic adaptor subunit	-
FPJ27_RS15710	2538670..2540694	+	2025	WP_204421733.1	MacB family efflux pump subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-173)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21393.01 Da
• Isoelectric Point: 5.3034

>T129239 WP_204421731.1 NZ_CP041778:2536447-2537028 [Burkholderia sp. MS455]
MNPDTIHARLDFLREAERLKNVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASPEARSAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTRRRIDAGGQRV

Nucleotide

• Length: 582 bp

>T129239 NZ_CP041778:2536447-2537028 [Burkholderia sp. MS455]
ATGAACCCCGACACGATCCACGCGCGCCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAGAACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGGCGCGCGGAAAGCACGGCCGAGCATAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGACGCGC
TGCCCGGCATCGATACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGATCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCACCCGGACAAAAGCGCGCACGAACGCGACGACCTGCTGACCCTGACGGCGTCGCTCGATCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAAGCAGCCGCGTCGCCGGAAGCGCGCTCGGCGAAGGCGC
TCGACAAGCTCGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGACGCCGCACCGCTGTTCAGTGCGATCCGCGATATCGTCGACGCGGATACGCGACGCCGGATCGA
CGCGGGCGGGCAGCGCGTGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20189.10 Da
• Isoelectric Point: 9.9889

>AT129239 WP_072441793.1 NZ_CP041778:2535810-2536367 [Burkholderia sp. MS455]
MTASPLYTPPLGPQLRRWRALHRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLPMLLGTSLWRYATPEIVRMEAALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT129239 NZ_CP041778:2535810-2536367 [Burkholderia sp. MS455]
ATGACCGCCTCACCGCTTTACACGCCACCGCTCGGCCCGCAGCTCAGGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCACGCCGCAGAATTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTCGCCGCGCGCCTCGATTCCGCAGGCGACCACGCGCTCGCGCGGCTCATCGCGGGC
AGCGCGGGCCGCATGCATCTGGTGTGCGACCTCACGCACCGCCTGCTCGCCAGTTCACCGGCGCGTGCGGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACACGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGACACCGGCGCGAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCACGTGCCGGTGGACGCGGATGACGCTGTCGGACGGCTCGGCCGCGCGGCTGGTCGAAACGCTCTAG

Structures

Antitoxin

• AlphaFold DB: A0A1K1RWE7