Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2006123..2006778 Replicon chromosome
Accession NZ_CP041778
Organism Burkholderia sp. MS455

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FPJ27_RS13640 Protein ID WP_204421467.1
Coordinates 2006123..2006542 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FPJ27_RS13645 Protein ID WP_204423192.1
Coordinates 2006539..2006778 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ27_RS13615 2001499..2002293 + 795 WP_204421464.1 AraC family transcriptional regulator -
FPJ27_RS13620 2002503..2003471 + 969 WP_204421465.1 DMT family transporter -
FPJ27_RS13625 2003657..2004229 + 573 WP_072442377.1 permease -
FPJ27_RS13630 2004329..2004463 - 135 WP_021158165.1 entericidin A/B family lipoprotein -
FPJ27_RS13635 2004697..2005992 + 1296 WP_204421466.1 aspartate carbamoyltransferase -
FPJ27_RS13640 2006123..2006542 - 420 WP_204421467.1 type II toxin-antitoxin system VapC family toxin Toxin
FPJ27_RS13645 2006539..2006778 - 240 WP_204423192.1 Arc family DNA-binding protein Antitoxin
FPJ27_RS13650 2007090..2009327 + 2238 WP_204421468.1 TonB-dependent siderophore receptor -
FPJ27_RS13655 2009331..2010086 + 756 WP_204421469.1 sel1 repeat family protein -
FPJ27_RS13660 2010083..2010766 + 684 WP_204421470.1 Fe2+-dependent dioxygenase -
FPJ27_RS13665 2010846..2011268 - 423 WP_034180480.1 amino acid-binding protein -
FPJ27_RS13670 2011475..2011714 + 240 WP_034180481.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-122)

Antitoxin

(7-46)


Sequences


Toxin        


Download         Length: 140 a.a.        Molecular weight: 15249.65 Da        Isoelectric Point: 5.9026

>T129237 WP_204421467.1 NZ_CP041778:c2006542-2006123 [Burkholderia sp. MS455]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAVLPEGRRREWLHQSIEQRVVPLFRGRILPFDD
AASKAYASLRARARVAGSAIAPVDCFIAATAEANGLIVATRDVAPFEAVGLRVIDPWAR

Download         Length: 420 bp

>T129237 NZ_CP041778:c2006542-2006123 [Burkholderia sp. MS455]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCCCTGCGACGCGAGCCGAGCGCAGCGGTGATCGAGTGGCTCGATGC
CCAGAACGTCGAGACGCTGTTTCTGGCTGCAATCAGTCTCGCGGAGATGCGATTCGGCGTGGCTGTATTGCCGGAAGGGC
GCAGGCGCGAGTGGCTGCATCAAAGCATCGAGCAGCGTGTCGTGCCGCTGTTTCGAGGCCGAATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGAGCCTGCGGGCTCGGGCCCGCGTCGCAGGTAGCGCGATCGCGCCTGTCGATTGTTTTAT
CGCCGCCACGGCCGAGGCGAACGGCCTGATCGTGGCCACGCGCGATGTCGCGCCGTTCGAGGCGGTGGGGCTTCGCGTGA
TCGATCCGTGGGCGCGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8645.82 Da        Isoelectric Point: 5.6864

>AT129237 WP_204423192.1 NZ_CP041778:c2006778-2006539 [Burkholderia sp. MS455]
MPVITVRNLPDEVHRALRVRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVDVDVQRDKTSTDPMSFE

Download         Length: 240 bp

>AT129237 NZ_CP041778:c2006778-2006539 [Burkholderia sp. MS455]
ATGCCGGTGATCACCGTTCGAAATTTGCCTGATGAAGTGCATCGCGCACTTCGGGTTCGCGCGGCCCAGCACGGACGAAG
CACCGAAGCCGAGGTACGTGACATTCTCGAACAGGCCGTCCTGCCAGGCGGGCGGCTCAAGCTGGGAACGTTGCTGGCGG
AAATCGGGCGGGAGGCTGGTGGAGTCGATGTCGACGTCCAGCGCGACAAGACGTCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References