Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1908525..1910272 Replicon chromosome
Accession NZ_CP041778
Organism Burkholderia sp. MS455

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag FPJ27_RS13135 Protein ID WP_204421414.1
Coordinates 1909376..1910272 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag FPJ27_RS13130 Protein ID WP_204421413.1
Coordinates 1908525..1909379 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ27_RS13110 1903671..1905161 - 1491 WP_072443352.1 aldehyde dehydrogenase -
FPJ27_RS13115 1905251..1906078 - 828 WP_204421410.1 aspartate dehydrogenase -
FPJ27_RS13120 1906071..1907738 - 1668 WP_204421411.1 thiamine pyrophosphate-binding protein -
FPJ27_RS13125 1907731..1908528 - 798 WP_204421412.1 SDR family oxidoreductase -
FPJ27_RS13130 1908525..1909379 - 855 WP_204421413.1 IclR family transcriptional regulator Antitoxin
FPJ27_RS13135 1909376..1910272 - 897 WP_204421414.1 alpha/beta fold hydrolase Toxin
FPJ27_RS13140 1910291..1910818 - 528 WP_034180369.1 cupin domain-containing protein -
FPJ27_RS13145 1910848..1911618 - 771 WP_204421415.1 SDR family oxidoreductase -
FPJ27_RS13150 1911611..1912681 - 1071 WP_204421416.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
FPJ27_RS13155 1912737..1913048 - 312 WP_034180372.1 hypothetical protein -
FPJ27_RS13160 1913050..1913367 - 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
FPJ27_RS13165 1913816..1914898 + 1083 WP_204421417.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30606.83 Da        Isoelectric Point: 7.7326

>T129236 WP_204421414.1 NZ_CP041778:c1910272-1909376 [Burkholderia sp. MS455]
MSVIDKRERDRTAAFATLLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPGRIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDTQWGLA

Download         Length: 897 bp

>T129236 NZ_CP041778:c1910272-1909376 [Burkholderia sp. MS455]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCATTCGCAACGCTGCTCGGACAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCAGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACGCGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTATGGCGTGTCGACGCCCGTGCACGGTGCGTCGCCGGCTGCCGCCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGGCCGGATCGCCGGCTTGCTGCTGGTGTCGCCTGCCGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GAGTCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGTCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCAGGTTACGCGC
AGGCCACGCATCTGCTCGCGAATGCCGATCTCGCGGCCGATCTCGCCGGTTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCCGCGGCCGCGCACGTTGGGCTGCAGGTTATTCCGCA
AGCCGGTCATGCCGGGTACGTGGAAGCGCCGGCCGTTTATTCCGCACTGATCGACACGTTCTGTCGTCAGTGTGATACGC
AGTGGGGTCTGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31278.84 Da        Isoelectric Point: 6.9861

>AT129236 WP_204421413.1 NZ_CP041778:c1909379-1908525 [Burkholderia sp. MS455]
MSEPLQQEPENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLKALRSLYPEGTLNRMTSATPETVDALYEVIREDVLRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVPR
PEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 855 bp

>AT129236 NZ_CP041778:c1909379-1908525 [Burkholderia sp. MS455]
ATGAGCGAACCGCTGCAACAAGAACCCGAAAACGGCAAGGCCGAGGCCAGCTACGTGGTGCCGGGCCTCGAACGCGGGCT
GCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAGTTGTCGAAGCGGCTCGGCATTCCGCGCA
CGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGTGCGGACAAGGATCGCAACTACAAGCTC
GGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGAGAG
CCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTCGTGTTCGTCGCGAAGGCGCAGA
GCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGAAGGCGCTGCGCTCGCTGTATCCGGAAGGCACGCTGAACCGGATGACGAGCGCGACGCC
GGAGACGGTCGATGCGTTGTACGAAGTGATCCGCGAGGATGTGCTGCGCGGCTATGGCGTCAGCAATTCGTCGTTCGAAC
GCGGCATCTCGGTGGTCACGGCACCGGTGCGAAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCGCGG
CCGGAGATCGACGCGGCGCTGATCGCGGACGGGTTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCGGCT
CAATTACCGCTCGGATGACGAGCACACGTTTATGAAGGCGTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References