Detailed information of TA system TA129235

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1441198..1442957
• Replicon: chromosome
• Accession: NZ_CP041778
• Organism: Burkholderia sp. MS455

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FPJ27_RS11115
• Protein ID: WP_204422907.1
• Coordinates: 1441198..1442538 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1K1N6Z5
• Locus tag: FPJ27_RS11120
• Protein ID: WP_072436796.1
• Coordinates: 1442541..1442957 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ27_RS11100	1436879..1438180	-	1302	WP_034179537.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
FPJ27_RS11105	1438382..1439689	-	1308	WP_072436793.1	shikimate transporter	-
FPJ27_RS11110	1440046..1441173	+	1128	WP_204422906.1	VOC family protein	-
FPJ27_RS11115	1441198..1442538	-	1341	WP_204422907.1	type II toxin-antitoxin system HipA family toxin	Toxin
FPJ27_RS11120	1442541..1442957	-	417	WP_072436796.1	helix-turn-helix domain-containing protein	Antitoxin
FPJ27_RS11125	1443361..1444380	+	1020	WP_204422908.1	DNA-binding protein	-
FPJ27_RS11130	1444481..1445101	+	621	WP_072436798.1	TetR/AcrR family transcriptional regulator	-
FPJ27_RS11135	1445338..1446396	+	1059	WP_204422909.1	NADP-dependent oxidoreductase	-
FPJ27_RS11140	1446496..1446795	+	300	WP_072436800.1	antibiotic biosynthesis monooxygenase	-
FPJ27_RS11145	1446935..1447390	+	456	WP_131948378.1	(2Fe-2S)-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-67)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 48895.85 Da
• Isoelectric Point: 8.1663

>T129235 WP_204422907.1 NZ_CP041778:c1442538-1441198 [Burkholderia sp. MS455]
MASRARHDRLDLWMNGIPVGYWEIRRGVERLVYLPGWLDDPQGRPLSLSLPFTPGNQPHQGAIVADYFDNLLPDSEPIRR
RIAQRYRLGSTAPFELLASIGRDCVGAIQMLPPGEMPVDLETIDGVALDDAAVADVLRHATAAPLPGRAEPDGDLRLSIA
GAQEKTALLRQGNRWLRPSGSTPTTHIFKLPLGRVGNMQADMRTSVENEWLCSKLVAAYGLPVAPCEIGRFDDQKALIVE
RFDRRPSRDGTWILRLPQEDMCQATGTPSGAKYESDGGPGIDTIMGILANSTDAAHDRMNFFVAQLVFWVLAAIDGHAKN
FSIAHLPGNTYRSTPLYDVLSAHPIIGTRRNQLPPRRARLAMAVRGKNRHYVIGEIQPRHWIAQGRRVGLTEDDVRVAMA
AVAARTEPAIAEVAAQIPVDFPADVADAIFNGMRRQSRKLGAGSAA

Nucleotide

• Length: 1341 bp

>T129235 NZ_CP041778:c1442538-1441198 [Burkholderia sp. MS455]
ATGGCATCGCGCGCCCGCCACGACCGGCTCGACCTGTGGATGAACGGCATTCCGGTCGGCTATTGGGAAATCCGGCGCGG
CGTCGAGCGCCTCGTCTACCTGCCGGGCTGGCTCGACGATCCCCAGGGGCGGCCGCTATCGCTTTCGCTGCCCTTTACGC
CCGGCAACCAGCCGCACCAGGGCGCGATCGTCGCCGACTACTTCGACAACCTGCTGCCGGACAGCGAGCCGATCCGCCGC
CGCATCGCGCAGCGTTACCGGCTCGGATCGACGGCACCGTTCGAACTGCTCGCGTCGATCGGCCGGGATTGCGTCGGCGC
GATCCAGATGCTGCCGCCCGGCGAAATGCCCGTTGACCTCGAGACGATCGACGGCGTGGCGCTCGACGACGCAGCCGTCG
CCGACGTGCTGCGCCACGCGACCGCCGCTCCGCTGCCCGGCCGCGCGGAGCCGGACGGCGACCTGCGCCTGTCGATCGCC
GGCGCGCAGGAAAAGACCGCATTGCTGCGTCAGGGAAACCGCTGGCTGCGGCCGTCGGGCAGCACGCCGACGACACACAT
TTTCAAGCTGCCGCTCGGGCGCGTCGGGAACATGCAGGCCGACATGCGGACGTCCGTCGAGAACGAATGGCTGTGCTCGA
AGCTCGTCGCCGCATACGGCCTGCCGGTCGCGCCGTGCGAGATCGGCCGGTTCGACGACCAGAAGGCGCTGATCGTCGAG
CGCTTCGACCGGCGTCCTTCGCGTGACGGCACGTGGATCCTGCGACTGCCGCAGGAGGACATGTGCCAGGCGACCGGCAC
GCCGTCCGGCGCGAAATACGAATCCGACGGCGGCCCCGGCATCGATACGATCATGGGCATCCTCGCGAATTCGACCGACG
CCGCGCACGACAGGATGAATTTCTTCGTCGCGCAGCTCGTGTTCTGGGTACTGGCGGCGATCGACGGCCACGCGAAGAAC
TTCAGCATCGCGCACCTGCCCGGCAATACGTACCGCAGCACGCCGCTGTACGACGTGCTGTCCGCGCATCCGATCATCGG
TACACGCCGCAACCAGTTGCCGCCGCGCCGCGCACGGCTCGCGATGGCCGTGCGCGGGAAGAACCGGCACTACGTGATCG
GCGAGATCCAGCCGCGTCACTGGATCGCGCAGGGGCGGCGCGTCGGCCTGACCGAAGATGACGTGCGCGTGGCGATGGCG
GCTGTCGCCGCGCGCACGGAACCCGCGATTGCCGAAGTCGCGGCGCAGATCCCGGTGGATTTTCCGGCGGATGTGGCGGA
CGCGATCTTCAACGGCATGCGTCGCCAGAGCCGCAAGCTCGGGGCGGGAAGTGCCGCGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 14560.78 Da
• Isoelectric Point: 11.7882

>AT129235 WP_072436796.1 NZ_CP041778:c1442957-1442541 [Burkholderia sp. MS455]
MAFPVQTLTQLRPILVGFRKSAGLTQAQLAARLGVTQQSYAQLEANPSAVSIERLFKVLNTLGVRMTLDLGAQDESAGPA
STDARPAAPKPAAKKRMPDPARGATAAKAQTKTTTGAARKRPATAAPGKPRVSKREDW

Nucleotide

• Length: 417 bp

>AT129235 NZ_CP041778:c1442957-1442541 [Burkholderia sp. MS455]
ATGGCCTTTCCTGTCCAGACCCTGACCCAGTTGCGCCCGATACTCGTCGGTTTCCGGAAATCCGCGGGGCTCACGCAGGC
GCAATTGGCCGCCCGCCTGGGCGTCACGCAGCAATCCTATGCGCAGCTCGAAGCCAATCCGTCGGCGGTGAGCATCGAAC
GGCTTTTCAAGGTGCTGAACACGCTTGGCGTTCGTATGACGCTCGACCTGGGCGCGCAGGACGAATCGGCGGGACCAGCC
AGTACCGATGCACGACCGGCGGCTCCCAAGCCGGCCGCGAAAAAGCGCATGCCGGACCCGGCGCGCGGCGCAACGGCCGC
AAAAGCTCAAACCAAAACCACGACCGGCGCCGCGCGCAAGCGGCCGGCGACAGCAGCGCCGGGCAAGCCACGGGTCTCGA
AACGGGAGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1K1N6Z5