Detailed information of TA system TA129233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1059300..1059946
• Replicon: chromosome
• Accession: NZ_CP041778
• Organism: Burkholderia sp. MS455

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPJ27_RS09415
• Protein ID: WP_204422699.1
• Coordinates: 1059539..1059946 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1K1MVH7
• Locus tag: FPJ27_RS09410
• Protein ID: WP_072436899.1
• Coordinates: 1059300..1059542 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPJ27_RS09395	1055291..1056697	+	1407	WP_204422696.1	aspartate ammonia-lyase	-
FPJ27_RS09400	1056801..1058306	+	1506	WP_204422697.1	amino acid permease	-
FPJ27_RS09405	1058357..1059040	-	684	WP_204422698.1	phospholipase	-
FPJ27_RS09410	1059300..1059542	+	243	WP_072436899.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FPJ27_RS09415	1059539..1059946	+	408	WP_204422699.1	type II toxin-antitoxin system VapC family toxin	Toxin
FPJ27_RS09420	1060248..1060466	-	219	WP_204422700.1	hypothetical protein	-
FPJ27_RS09425	1060524..1062902	+	2379	WP_204422701.1	MCP four helix bundle domain-containing protein	-
FPJ27_RS09430	1062925..1063653	+	729	WP_204423136.1	chemotaxis protein	-
FPJ27_RS09435	1063650..1064222	+	573	WP_204422702.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14870.06 Da
• Isoelectric Point: 6.4914

>T129233 WP_204422699.1 NZ_CP041778:1059539-1059946 [Burkholderia sp. MS455]
MKFLLDTNAVIAILKGELAMLAKLRAHRPADFGIPAIVAHELYYGAYKSQRVAANLARVEGLQFEVVSFDAEDAQHAGEI
RAHLTAAGTPIGPYDALIAGQARARRLVLVTHNMREFERVPELQIEDWLAGAHEN

Nucleotide

• Length: 408 bp

>T129233 NZ_CP041778:1059539-1059946 [Burkholderia sp. MS455]
ATGAAGTTTCTGCTGGATACCAACGCGGTAATCGCCATTCTCAAAGGCGAGCTGGCCATGCTGGCCAAGCTGCGTGCGCA
TCGACCGGCAGACTTCGGAATTCCGGCGATCGTCGCGCATGAGCTCTATTACGGAGCTTACAAAAGTCAGCGAGTGGCAG
CCAATCTGGCGCGCGTGGAGGGGCTTCAGTTCGAGGTCGTGTCGTTCGACGCGGAAGATGCTCAGCATGCTGGCGAAATT
CGTGCGCATTTGACCGCGGCAGGAACACCGATCGGCCCATATGATGCATTGATCGCAGGGCAGGCGCGTGCGCGGCGGCT
GGTGCTTGTCACGCATAACATGCGCGAGTTTGAGCGAGTCCCGGAGCTGCAGATCGAGGATTGGCTCGCAGGCGCGCATG
AAAACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8985.19 Da
• Isoelectric Point: 4.7483

>AT129233 WP_072436899.1 NZ_CP041778:1059300-1059542 [Burkholderia sp. MS455]
MDIAKIFKHGGSQAVRLPKDFRFETTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAATTQPDVQERPGLDVFE

Nucleotide

• Length: 243 bp

>AT129233 NZ_CP041778:1059300-1059542 [Burkholderia sp. MS455]
ATGGATATTGCCAAGATCTTCAAGCATGGCGGATCGCAGGCCGTCCGGCTGCCGAAGGATTTCCGCTTCGAGACGACCGA
GGTTCGGATTCGCCGCCACGGGGCGTCCGTCATTCTCGAGCCGGTGCCGCAAGACTGGGCATGGCTGACACCGCTGATCG
GCCCGGTCGACGCCGACTTCGAGGCCGCTGCAACAACCCAGCCGGACGTTCAAGAGCGCCCGGGACTGGACGTGTTTGAA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1K1MVH7