129224

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 158163..158668 Replicon chromosome
Accession NZ_CP041774
Organism Pseudomonas aeruginosa strain 60503

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag FOY97_RS00740 Protein ID WP_003083773.1
Coordinates 158163..158444 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag FOY97_RS00745 Protein ID WP_003083775.1
Coordinates 158441..158668 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY97_RS00715 153414..154763 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
FOY97_RS00720 154812..155498 + 687 WP_003083762.1 FadR family transcriptional regulator -
FOY97_RS00725 155599..156333 + 735 WP_003110658.1 GntR family transcriptional regulator -
FOY97_RS00730 156537..156923 + 387 WP_003083767.1 aegerolysin family protein -
FOY97_RS00735 156955..157863 - 909 WP_003083769.1 LysR family transcriptional regulator -
FOY97_RS00740 158163..158444 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
FOY97_RS00745 158441..158668 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
FOY97_RS00750 158844..159464 - 621 WP_003101226.1 hypothetical protein -
FOY97_RS00755 159565..160065 + 501 WP_003162763.1 LEA type 2 family protein -
FOY97_RS00760 160138..160479 + 342 WP_003101229.1 alkylphosphonate utilization protein -
FOY97_RS00765 160561..161988 - 1428 WP_003083784.1 GABA permease -
FOY97_RS00770 162157..163650 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T129224 WP_003083773.1 NZ_CP041774:c158444-158163 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T129224 NZ_CP041774:c158444-158163 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGTAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT129224 WP_003083775.1 NZ_CP041774:c158668-158441 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT129224 NZ_CP041774:c158668-158441 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References