Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2649984..2650489 Replicon chromosome
Accession NZ_CP041773
Organism Pseudomonas aeruginosa strain 519119

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag FOY95_RS12715 Protein ID WP_003083773.1
Coordinates 2649984..2650265 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag FOY95_RS12720 Protein ID WP_003083775.1
Coordinates 2650262..2650489 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY95_RS12690 2645235..2646584 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
FOY95_RS12695 2646633..2647319 + 687 WP_003083762.1 FadR family transcriptional regulator -
FOY95_RS12700 2647420..2648154 + 735 WP_003117208.1 GntR family transcriptional regulator -
FOY95_RS12705 2648358..2648744 + 387 WP_014602345.1 aegerolysin family protein -
FOY95_RS12710 2648776..2649684 - 909 WP_003083769.1 LysR family transcriptional regulator -
FOY95_RS12715 2649984..2650265 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
FOY95_RS12720 2650262..2650489 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
FOY95_RS12725 2650665..2651285 - 621 WP_009314940.1 hypothetical protein -
FOY95_RS12730 2651386..2651886 + 501 WP_003112629.1 LEA type 2 family protein -
FOY95_RS12735 2651959..2652300 + 342 WP_003101229.1 alkylphosphonate utilization protein -
FOY95_RS12740 2652382..2653809 - 1428 WP_003083784.1 GABA permease -
FOY95_RS12745 2653978..2655471 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T129221 WP_003083773.1 NZ_CP041773:c2650265-2649984 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T129221 NZ_CP041773:c2650265-2649984 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT129221 WP_003083775.1 NZ_CP041773:c2650489-2650262 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT129221 NZ_CP041773:c2650489-2650262 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References