Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 146012..146517 Replicon chromosome
Accession NZ_CP041771
Organism Pseudomonas aeruginosa strain A681

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag FOY61_RS00695 Protein ID WP_003083773.1
Coordinates 146012..146293 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag FOY61_RS00700 Protein ID WP_003112628.1
Coordinates 146290..146517 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOY61_RS00670 141263..142612 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
FOY61_RS00675 142661..143347 + 687 WP_004351997.1 FadR family transcriptional regulator -
FOY61_RS00680 143448..144182 + 735 WP_003117208.1 GntR family transcriptional regulator -
FOY61_RS00685 144386..144772 + 387 WP_014602345.1 aegerolysin family protein -
FOY61_RS00690 144804..145712 - 909 WP_003083769.1 LysR family transcriptional regulator -
FOY61_RS00695 146012..146293 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
FOY61_RS00700 146290..146517 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
FOY61_RS00705 146692..147312 - 621 WP_009314940.1 hypothetical protein -
FOY61_RS00710 147420..147920 + 501 WP_003112629.1 LEA type 2 family protein -
FOY61_RS00715 147993..148334 + 342 WP_003101229.1 alkylphosphonate utilization protein -
FOY61_RS00720 148416..149843 - 1428 WP_003083784.1 GABA permease -
FOY61_RS00725 150012..151505 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T129207 WP_003083773.1 NZ_CP041771:c146293-146012 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T129207 NZ_CP041771:c146293-146012 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGAAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT129207 WP_003112628.1 NZ_CP041771:c146517-146290 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT129207 NZ_CP041771:c146517-146290 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAAAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References