Detailed information of TA system TA129201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1085730..1086391
• Replicon: chromosome
• Accession: NZ_CP041765
• Organism: Tomitella sp. HY188

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FO059_RS05000
• Protein ID: WP_143906881.1
• Coordinates: 1085966..1086391 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FO059_RS04995
• Protein ID: WP_143906879.1
• Coordinates: 1085730..1085969 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO059_RS04965	1081009..1082022	-	1014	WP_143906871.1	OB-fold nucleic acid binding domain-containing protein	-
FO059_RS04970	1082132..1083166	+	1035	WP_143906873.1	LLM class F420-dependent oxidoreductase	-
FO059_RS04975	1083255..1083902	+	648	WP_143910449.1	DedA family protein	-
FO059_RS04980	1084019..1084375	-	357	WP_143906875.1	amino acid permease	-
FO059_RS18535	1084429..1084665	+	237	WP_210416625.1	hypothetical protein	-
FO059_RS04990	1084681..1085619	+	939	WP_143906877.1	hypothetical protein	-
FO059_RS04995	1085730..1085969	+	240	WP_143906879.1	plasmid stability protein	Antitoxin
FO059_RS05000	1085966..1086391	+	426	WP_143906881.1	type II toxin-antitoxin system VapC family toxin	Toxin
FO059_RS05005	1086478..1087116	-	639	WP_143906883.1	hypothetical protein	-
FO059_RS05010	1087237..1087536	+	300	WP_158726606.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
FO059_RS05015	1087548..1088402	-	855	WP_143906887.1	crotonase/enoyl-CoA hydratase family protein	-
FO059_RS05020	1088548..1090182	+	1635	WP_143906889.1	acyl-CoA synthetase	-
FO059_RS05025	1090191..1091315	+	1125	WP_143906891.1	nitronate monooxygenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14824.08 Da
• Isoelectric Point: 6.4697

>T129201 WP_143906881.1 NZ_CP041765:1085966-1086391 [Tomitella sp. HY188]
VIILDTNVLSEPIRSSPHAGVIRWLDAQAMETLWLTAITVAEIHYGIASLADGRRRIAPGGRIDNEVLPKFGGRVLEFGL
AEAVAYADLRADARRVGRAIGGLDALIAAIAVSRSATVATRDAAPFVAAGVPVINPFVVSD

Nucleotide

• Length: 426 bp

>T129201 NZ_CP041765:1085966-1086391 [Tomitella sp. HY188]
GTGATCATCCTCGACACCAACGTGCTGTCGGAGCCGATCCGCAGTTCTCCGCACGCGGGCGTCATCCGGTGGCTCGACGC
GCAGGCGATGGAGACGCTGTGGCTCACGGCCATCACCGTCGCGGAGATCCATTACGGGATAGCGTCACTGGCGGACGGGC
GGCGGAGGATCGCGCCCGGCGGCCGGATCGACAACGAGGTGCTCCCGAAGTTCGGCGGGCGGGTGCTCGAATTCGGCCTG
GCTGAAGCGGTCGCGTATGCGGATCTGCGGGCCGATGCCCGGCGCGTGGGCCGTGCCATAGGTGGCCTCGACGCGCTGAT
CGCCGCGATCGCGGTCTCCCGCTCGGCCACGGTCGCCACTAGAGACGCCGCCCCGTTCGTCGCTGCCGGCGTCCCGGTGA
TCAACCCGTTCGTCGTATCCGATTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8542.71 Da
• Isoelectric Point: 5.5882

>AT129201 WP_143906879.1 NZ_CP041765:1085730-1085969 [Tomitella sp. HY188]
MAAITIRNLSAETHRALKARAAMHNRSTETEVRAIVDAAVLPADRVRLGSLLAGIGEEIGGIDLDIERDRSPHDPMDLT

Nucleotide

• Length: 240 bp

>AT129201 NZ_CP041765:1085730-1085969 [Tomitella sp. HY188]
ATGGCCGCCATCACGATCCGCAACCTCTCCGCGGAGACGCACCGCGCGCTCAAGGCCCGGGCTGCAATGCACAACCGCAG
CACCGAGACGGAGGTGCGCGCGATCGTCGACGCCGCCGTGCTCCCCGCCGACCGCGTACGGCTCGGCAGCCTGCTCGCGG
GCATCGGCGAGGAGATCGGCGGCATCGACCTGGACATCGAACGGGATCGCTCGCCGCACGACCCGATGGACCTGACGTGA