Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 80332..80896 Replicon chromosome
Accession NZ_CP041765
Organism Tomitella sp. HY188

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FO059_RS00360 Protein ID WP_168226635.1
Coordinates 80546..80896 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FO059_RS00355 Protein ID WP_143905405.1
Coordinates 80332..80562 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO059_RS00330 76003..76899 + 897 WP_143905395.1 MBL fold metallo-hydrolase -
FO059_RS00335 76896..77846 + 951 WP_143905397.1 ABC transporter substrate-binding protein -
FO059_RS00340 77843..78676 + 834 WP_143905399.1 ABC transporter permease -
FO059_RS00345 78678..79436 + 759 WP_143905401.1 ABC transporter permease -
FO059_RS00350 79433..80278 + 846 WP_143905403.1 ABC transporter ATP-binding protein -
FO059_RS00355 80332..80562 + 231 WP_143905405.1 ribbon-helix-helix domain-containing protein Antitoxin
FO059_RS00360 80546..80896 + 351 WP_168226635.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FO059_RS00365 80913..82046 - 1134 WP_143905409.1 RNA polymerase subunit sigma-24 -
FO059_RS00370 82046..82444 - 399 WP_143905411.1 hypothetical protein -
FO059_RS00375 82620..83591 + 972 WP_143905413.1 zinc-binding dehydrogenase -
FO059_RS00380 83661..85172 - 1512 WP_143905415.1 DHA2 family efflux MFS transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12569.65 Da        Isoelectric Point: 11.3028

>T129200 WP_168226635.1 NZ_CP041765:80546-80896 [Tomitella sp. HY188]
MMLRGEVRLVNLEPARGSEANKKRPAVIVSNDRANATAARLGRGVVTVVLVTSSTARLYPFQVLLDSEVTGLRMDSKAQA
EQVRSVAVERIGPVIARLPAPTMNALDDALRLHLQL

Download         Length: 351 bp

>T129200 NZ_CP041765:80546-80896 [Tomitella sp. HY188]
CTGATGCTGCGCGGTGAGGTGCGGCTGGTCAATCTGGAACCGGCTCGCGGAAGCGAGGCGAACAAGAAGCGTCCGGCGGT
CATCGTCAGCAATGACAGGGCCAACGCGACGGCGGCGCGCCTGGGCCGTGGTGTGGTGACGGTAGTGCTGGTGACCAGCA
GCACCGCCCGGCTGTATCCGTTCCAGGTTCTCCTCGACTCCGAGGTCACCGGGCTTCGTATGGATTCGAAGGCGCAGGCG
GAACAGGTCCGTTCAGTCGCGGTCGAACGTATCGGGCCGGTGATCGCACGTCTGCCTGCGCCGACGATGAATGCGCTCGA
CGACGCGCTCCGGTTGCACCTGCAACTGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.00 Da        Isoelectric Point: 3.9251

>AT129200 WP_143905405.1 NZ_CP041765:80332-80562 [Tomitella sp. HY188]
VKISVSLPEEDLEILDSYMRESGLGSRSAAIQRAVRMLRNVDLEDDYAAAWSEWESSGDAAAWESVAGDGLADAAR

Download         Length: 231 bp

>AT129200 NZ_CP041765:80332-80562 [Tomitella sp. HY188]
GTGAAGATCAGCGTGAGCCTGCCGGAAGAGGACCTCGAGATTCTCGACTCGTACATGCGGGAATCCGGGCTGGGGTCACG
TTCCGCCGCAATCCAGCGGGCGGTCAGGATGCTCCGGAATGTCGATCTGGAAGACGATTACGCGGCGGCGTGGAGCGAGT
GGGAGTCGTCCGGCGACGCTGCCGCTTGGGAGTCGGTGGCGGGGGACGGTCTCGCTGATGCTGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References