Detailed information of TA system TA129190

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 981303..981934
• Replicon: chromosome
• Accession: NZ_CP041764
• Organism: Serratia rhizosphaerae strain KUDC3025

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: L0MF14
• Locus tag: FO014_RS04670
• Protein ID: WP_015671220.1
• Coordinates: 981731..981934 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: FO014_RS04665
• Protein ID: WP_105230044.1
• Coordinates: 981303..981671 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO014_RS04635	977427..977681	+	255	WP_015671227.1	type B 50S ribosomal protein L31	-
FO014_RS04640	977691..977831	+	141	WP_004940304.1	type B 50S ribosomal protein L36	-
FO014_RS04645	977929..978804	-	876	WP_160028051.1	metal ABC transporter substrate-binding protein	-
FO014_RS04650	978820..979686	-	867	WP_160028053.1	metal ABC transporter permease	-
FO014_RS04655	979683..980387	-	705	WP_160031352.1	ABC transporter ATP-binding protein	-
FO014_RS23750	980384..980530	-	147	WP_201282916.1	hypothetical protein	-
FO014_RS04660	980699..981052	+	354	WP_160028055.1	hypothetical protein	-
FO014_RS04665	981303..981671	+	369	WP_105230044.1	Hha toxicity modulator TomB	Antitoxin
FO014_RS04670	981731..981934	+	204	WP_015671220.1	hemolysin expression modulator Hha	Toxin
FO014_RS04675	982009..982941	-	933	WP_160028057.1	LysR family transcriptional regulator	-
FO014_RS04680	983080..984867	+	1788	WP_160028059.1	amidohydrolase family protein	-
FO014_RS04685	984937..986280	+	1344	WP_160028061.1	NCS2 family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8049.33 Da
• Isoelectric Point: 7.9816

>T129190 WP_015671220.1 NZ_CP041764:981731-981934 [Serratia rhizosphaerae]
MTKTDYLMRLRKCTTIDTLERVIEKNKYALSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Nucleotide

• Length: 204 bp

>T129190 NZ_CP041764:981731-981934 [Serratia rhizosphaerae]
ATGACAAAAACCGACTACCTGATGCGTTTACGTAAATGCACCACTATCGATACGCTTGAAAGAGTGATTGAAAAAAACAA
ATATGCGCTTTCTGATGATGAGCTCGAACTGTTTTACTCGGCAGCCGACCACCGTCTGGCGGAACTCACCATGAATAAAC
TGTACGACAAAATTCCAACATCTGTTTGGAAATATGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14350.17 Da
• Isoelectric Point: 4.6346

>AT129190 WP_105230044.1 NZ_CP041764:981303-981671 [Serratia rhizosphaerae]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSYKIKYMDESDFSELVEEYL
DDTYTLFSNYGINDSDLRRWQKTKLRLFRMFSGEVCCTKMKT

Nucleotide

• Length: 369 bp

>AT129190 NZ_CP041764:981303-981671 [Serratia rhizosphaerae]
ATGGATGAGTACTCGCCGAAACGGCATGATATTGCTCAACTCAAATTCTTGTGTGAGAATCTGTACGATGAAGGCATTGC
GACGTTGGGCGACAGCCACCACGGCTGGGTCAACGATCCGACATCGGCCGTCAATCTGCAGCTGAATGAGCTGATCGAAC
ATATTGCTTCGTTTGTGATGAGTTATAAAATAAAATACATGGACGAAAGTGACTTTTCAGAATTAGTCGAAGAGTATCTC
GACGATACCTACACGTTATTTAGTAACTACGGTATTAACGATTCCGATCTGCGCCGTTGGCAAAAAACCAAACTGCGATT
ATTCAGAATGTTCTCAGGAGAGGTTTGCTGTACGAAAATGAAAACTTAG

Structures

Toxin

• AlphaFold DB: A0A857EAE6