Detailed information of TA system TA129156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 5234312..5234825
• Replicon: chromosome
• Accession: NZ_CP041753
• Organism: Pseudomonas sp. ATCC 43928

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FFH90_RS23945
• Protein ID: WP_082920901.1
• Coordinates: 5234541..5234825 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2W7J5D4
• Locus tag: FFH90_RS23940
• Protein ID: WP_019647939.1
• Coordinates: 5234312..5234551 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFH90_RS23905	5229963..5230493	+	531	WP_064619797.1	DUF2867 domain-containing protein	-
FFH90_RS23910	5230702..5231109	+	408	WP_064619800.1	low affinity iron permease family protein	-
FFH90_RS23915	5231152..5231655	-	504	WP_086944815.1	DUF4142 domain-containing protein	-
FFH90_RS23920	5231730..5231885	-	156	WP_081791039.1	stress protein	-
FFH90_RS23925	5232002..5233351	-	1350	WP_138866203.1	sensor domain-containing diguanylate cyclase	-
FFH90_RS23930	5233455..5233694	-	240	Protein_4605	LysE family translocator	-
FFH90_RS23935	5233731..5234147	-	417	WP_138866204.1	fosfomycin resistance glutathione transferase	-
FFH90_RS23940	5234312..5234551	+	240	WP_019647939.1	CopG family ribbon-helix-helix protein	Antitoxin
FFH90_RS23945	5234541..5234825	+	285	WP_082920901.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FFH90_RS23950	5234923..5236254	-	1332	WP_064619812.1	MFS transporter	-
FFH90_RS23955	5236346..5237272	-	927	WP_138866205.1	hydroxymethylglutaryl-CoA lyase	-
FFH90_RS23960	5237269..5238462	-	1194	WP_138866206.1	CoA transferase	-
FFH90_RS23965	5238627..5239535	-	909	WP_111454820.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10894.71 Da
• Isoelectric Point: 11.0304

>T129156 WP_082920901.1 NZ_CP041753:5234541-5234825 [Pseudomonas sp. ATCC 43928]
MRVEWLRTALKNLDDEAAYIAMENPKAAADFVKAILTTVDHLARFPATGREGRLPGTREWVLPDRPYLIPYRVRQGRLQV
LRVFHTRRLPPTTL

Nucleotide

• Length: 285 bp

>T129156 NZ_CP041753:5234541-5234825 [Pseudomonas sp. ATCC 43928]
ATGCGCGTTGAGTGGTTGCGTACCGCATTAAAGAATCTGGATGACGAAGCCGCCTACATAGCAATGGAAAATCCAAAAGC
CGCAGCAGACTTCGTCAAGGCCATTCTCACCACCGTCGATCACCTTGCTCGCTTCCCGGCTACAGGCCGCGAAGGCCGAC
TACCTGGCACTCGGGAATGGGTCTTGCCAGACCGGCCCTATCTGATTCCCTATCGAGTTCGCCAAGGGCGTTTACAGGTA
CTACGAGTCTTCCATACACGACGCCTTCCACCCACTACGTTGTAG

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8788.99 Da
• Isoelectric Point: 4.8096

>AT129156 WP_019647939.1 NZ_CP041753:5234312-5234551 [Pseudomonas sp. ATCC 43928]
MSIMSLRLPDEIADTLAHLAKATGRSKSFLAVDALREYLAREAWQIEEIQKALKEADAGDFATPEEVKAIADKWTTNAR

Nucleotide

• Length: 240 bp

>AT129156 NZ_CP041753:5234312-5234551 [Pseudomonas sp. ATCC 43928]
ATGTCCATCATGTCGCTGCGTTTGCCAGACGAAATCGCCGATACCCTAGCCCATCTTGCCAAAGCGACAGGCCGCAGTAA
GTCATTTCTGGCCGTGGATGCGCTGCGTGAATATCTGGCACGGGAAGCCTGGCAAATCGAAGAGATTCAGAAAGCTCTGA
AAGAAGCCGACGCGGGTGACTTCGCAACGCCAGAGGAAGTGAAAGCAATCGCCGACAAGTGGACAACCAATGCGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2W7J5D4