Detailed information of TA system TA129155

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5222734..5223357
• Replicon: chromosome
• Accession: NZ_CP041753
• Organism: Pseudomonas sp. ATCC 43928

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: J3GAV2
• Locus tag: FFH90_RS23855
• Protein ID: WP_007984690.1
• Coordinates: 5222734..5222913 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FFH90_RS23860
• Protein ID: WP_138866200.1
• Coordinates: 5222950..5223357 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFH90_RS23835	5217818..5218504	-	687	WP_138866199.1	cytochrome c oxidase subunit 3	-
FFH90_RS23840	5218501..5220276	-	1776	WP_064619781.1	cytochrome c oxidase subunit I	-
FFH90_RS23845	5220325..5221797	-	1473	WP_138866812.1	cytochrome c oxidase subunit II	-
FFH90_RS23850	5222119..5222466	+	348	WP_111454828.1	hypothetical protein	-
FFH90_RS23855	5222734..5222913	+	180	WP_007984690.1	type II toxin-antitoxin system HicA family toxin	Toxin
FFH90_RS23860	5222950..5223357	+	408	WP_138866200.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FFH90_RS23865	5223409..5224176	-	768	WP_111454827.1	trans-aconitate 2-methyltransferase	-
FFH90_RS23870	5224248..5224577	-	330	WP_018926816.1	YXWGXW repeat-containing protein	-
FFH90_RS23875	5225019..5225522	+	504	WP_138866201.1	inclusion body family protein	-
FFH90_RS23880	5225648..5226187	+	540	WP_111454826.1	hypothetical protein	-
FFH90_RS23885	5226272..5226730	-	459	WP_018926819.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6704.97 Da
• Isoelectric Point: 11.4113

>T129155 WP_007984690.1 NZ_CP041753:5222734-5222913 [Pseudomonas sp. ATCC 43928]
VNSRFLISQIVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Nucleotide

• Length: 180 bp

>T129155 NZ_CP041753:5222734-5222913 [Pseudomonas sp. ATCC 43928]
GTGAATAGCCGGTTTTTGATAAGCCAAATCGTCGCGGACGGCTGGTATCTGGTACGAATCAGGGGGAGTCATCACCACTT
CAAGCATCCGACCAAGCCTGGACTGGTGACGGTTCCTCACCCGAAAAAGGACCTGCTCAAGAAAACGGCCATTAGTATTT
TGCAACAGGCGCTGCTCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14632.55 Da
• Isoelectric Point: 4.3833

>AT129155 WP_138866200.1 NZ_CP041753:5222950-5223357 [Pseudomonas sp. ATCC 43928]
MLYPIAISTGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPQYAGCTWAV
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQS

Nucleotide

• Length: 408 bp

>AT129155 NZ_CP041753:5222950-5223357 [Pseudomonas sp. ATCC 43928]
ATGCTTTACCCCATCGCGATTTCCACGGGTGATGACGAACACGCCTGGGGCGTAGAAGTTCCGGATATTCCAGGTTGCTT
CTCCGCCGGGGAAGATCTGGATGACGCCATGGCCATGGCTCGCGAAGCCATCGAAGGTCATTTCGAGATTCTGGCCGAAG
ACGGATCACCGATTCCGCCCGCCAACAAAGTGACCCTGCATGCGGCTAATCCACAGTACGCAGGGTGCACGTGGGCCGTG
GTGGATATCGATGTCACCAAATACCTGGGCAAGGCGCAGAAACTCAACATCACCCTGCCCGGCTATCTGCTCAACCGCAT
CGATGAGTACGTATTGCACCATCCGGAAGAGAAAAGTCGCTCCGGGTTTCTGGCCTCGGCGGCGCTCAAGGTCTTGCAGC
AAAGTTGA

Structures

Toxin

• AlphaFold DB: J3GAV2