Detailed information of TA system TA129150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 484036..484679
• Replicon: chromosome
• Accession: NZ_CP041753
• Organism: Pseudomonas sp. ATCC 43928

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FFH90_RS02165
• Protein ID: WP_018929327.1
• Coordinates: 484036..484218 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FFH90_RS02170
• Protein ID: WP_008005174.1
• Coordinates: 484215..484679 (+)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FFH90_RS02145	479864..481819	+	1956	WP_018929331.1	choline transporter BetT	-
FFH90_RS02150	481834..482094	-	261	WP_018929330.1	hypothetical protein	-
FFH90_RS02155	482151..482891	-	741	WP_019651514.1	SDR family oxidoreductase	-
FFH90_RS02160	483017..483907	+	891	WP_138866625.1	LysR family transcriptional regulator	-
FFH90_RS02165	484036..484218	+	183	WP_018929327.1	type II toxin-antitoxin system HicA family toxin	Toxin
FFH90_RS02170	484215..484679	+	465	WP_008005174.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FFH90_RS02175	484846..485883	+	1038	WP_018929326.1	L-glyceraldehyde 3-phosphate reductase	-
FFH90_RS02180	485937..486779	-	843	WP_086944163.1	taurine dioxygenase	-
FFH90_RS02185	486819..487667	-	849	WP_018929324.1	taurine ABC transporter permease TauC	-
FFH90_RS02190	487664..488458	-	795	WP_018929323.1	taurine ABC transporter ATP-binding subunit	-
FFH90_RS02195	488475..489452	-	978	WP_018929322.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (24-148)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6873.01 Da
• Isoelectric Point: 10.3203

>T129150 WP_018929327.1 NZ_CP041753:484036-484218 [Pseudomonas sp. ATCC 43928]
MRSREMIRMIEEDGWYLVAVKGSHHQYKHPCKSGRVTIKHPDSDLPKGTINSILKQAGLK

Nucleotide

• Length: 183 bp

>T129150 NZ_CP041753:484036-484218 [Pseudomonas sp. ATCC 43928]
ATGCGAAGTCGGGAAATGATCAGGATGATCGAGGAGGATGGTTGGTATCTGGTGGCCGTGAAAGGTAGCCATCATCAGTA
CAAGCACCCGTGTAAGTCAGGCAGGGTGACGATAAAACACCCTGATTCGGATCTTCCAAAAGGCACGATCAACAGCATAT
TGAAACAGGCGGGTCTGAAATGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 16808.81 Da
• Isoelectric Point: 4.2692

>AT129150 WP_008005174.1 NZ_CP041753:484215-484679 [Pseudomonas sp. ATCC 43928]
MRPDIGNESLEGATSQEGLIEMKFPVVLHKDADSEYGVIIPDVPGCFSAGATVAQAFENVKEALALHYEGLVADGDPLPQ
VREIDAHLDNPDYAGGVWGVVEFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Nucleotide

• Length: 465 bp

>AT129150 NZ_CP041753:484215-484679 [Pseudomonas sp. ATCC 43928]
ATGAGGCCCGACATCGGAAACGAAAGCCTCGAAGGGGCCACATCACAGGAAGGACTCATCGAAATGAAATTCCCGGTCGT
TCTGCACAAGGATGCCGACTCAGAATACGGAGTGATTATCCCGGACGTGCCGGGATGCTTCTCCGCAGGCGCTACAGTGG
CGCAGGCATTTGAAAACGTGAAAGAAGCGTTGGCTTTGCACTACGAAGGTCTGGTCGCCGATGGTGATCCACTTCCGCAG
GTGCGTGAAATTGACGCTCATCTTGATAACCCTGATTACGCTGGCGGTGTGTGGGGTGTGGTCGAATTCGATATCACACC
CTATTTCGGCAAGTCGGTGCGCTTCAATGCCACGCTTCCTGAGCAGTTGCTTGAGCGTATCGATCAGACGGTCAGACGAG
ATCAGCGATATAGCTCAAGGTCTGGCTTTTTGGCGGCTGCCGCGCTACGTGAGTTGTCGGCGTAA