Detailed information of TA system TA129141

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4625683..4626515
• Replicon: chromosome
• Accession: NZ_CP041749
• Organism: Escherichia coli strain NCCP 15955

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A2A2C6E0
• Locus tag: FOV95_RS22545
• Protein ID: WP_000854716.1
• Coordinates: 4625683..4626057 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A3U2KGT7
• Locus tag: FOV95_RS22550
• Protein ID: WP_001285595.1
• Coordinates: 4626147..4626515 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOV95_RS22510	4620743..4621492	-	750	WP_000440471.1	chitin disaccharide deacetylase	-
FOV95_RS22515	4621505..4622857	-	1353	WP_000078757.1	6-phospho-beta-glucosidase	-
FOV95_RS22520	4622962..4623804	-	843	WP_000983647.1	transcriptional regulator ChbR	-
FOV95_RS22525	4623812..4623916	-	105	Protein_4381	PTS lactose/cellobiose transporter subunit IIA	-
FOV95_RS22530	4624056..4624901	-	846	WP_001280505.1	DUF4942 domain-containing protein	-
FOV95_RS22535	4624986..4625183	-	198	WP_000839249.1	DUF957 domain-containing protein	-
FOV95_RS22540	4625195..4625686	-	492	WP_159394908.1	hypothetical protein	-
FOV95_RS22545	4625683..4626057	-	375	WP_000854716.1	TA system toxin CbtA family protein	Toxin
FOV95_RS22550	4626147..4626515	-	369	WP_001285595.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
FOV95_RS22555	4626572..4626811	-	240	WP_000692304.1	DUF987 domain-containing protein	-
FOV95_RS22560	4626874..4627350	-	477	WP_001186727.1	RadC family protein	-
FOV95_RS22565	4627366..4627851	-	486	WP_000213717.1	antirestriction protein	-
FOV95_RS22570	4627943..4628761	-	819	WP_033801547.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4609522..4637886	28364

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13986.02 Da
• Isoelectric Point: 7.2426

>T129141 WP_000854716.1 NZ_CP041749:c4626057-4625683 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYLEAK

Nucleotide

• Length: 375 bp

>T129141 NZ_CP041749:c4626057-4625683 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGATTCTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCTGGAGGCGAAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13494.33 Da
• Isoelectric Point: 6.3132

>AT129141 WP_001285595.1 NZ_CP041749:c4626515-4626147 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTSCFGARLVQVGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT129141 NZ_CP041749:c4626515-4626147 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GTCCTGTTTCGGCGCCCGTCTGGTGCAGGTGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGTTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A2A2C6E0

Antitoxin

• AlphaFold DB: A0A3U2KGT7