Detailed information of TA system TA129137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 3884624..3885103
• Replicon: chromosome
• Accession: NZ_CP041749
• Organism: Escherichia coli strain NCCP 15955

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A234Y3J1
• Locus tag: FOV95_RS18700
• Protein ID: WP_001444087.1
• Coordinates: 3884624..3884911 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A234Y267
• Locus tag: FOV95_RS18705
• Protein ID: WP_001090455.1
• Coordinates: 3884915..3885103 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOV95_RS18665	3879836..3880105	-	270	WP_000003742.1	excisionase	-
FOV95_RS18670	3880167..3882569	-	2403	WP_022581375.1	exonuclease	-
FOV95_RS18675	3882662..3882850	-	189	WP_022581374.1	DUF1482 family protein	-
FOV95_RS18680	3882847..3883035	-	189	WP_000450222.1	cell division inhibitor	-
FOV95_RS23645	3883332..3883469	+	138	WP_022581373.1	hypothetical protein	-
FOV95_RS18690	3883820..3884188	-	369	WP_028985920.1	hypothetical protein	-
FOV95_RS18695	3884200..3884352	-	153	WP_000380321.1	DUF1391 family protein	-
FOV95_RS18700	3884624..3884911	-	288	WP_001444087.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOV95_RS18705	3884915..3885103	-	189	WP_001090455.1	hypothetical protein	Antitoxin
FOV95_RS18710	3885133..3885531	-	399	WP_000209117.1	helix-turn-helix domain-containing protein	-
FOV95_RS18715	3885648..3885926	+	279	WP_000548554.1	helix-turn-helix domain-containing protein	-
FOV95_RS18720	3885910..3886431	+	522	WP_000705386.1	hypothetical protein	-
FOV95_RS18725	3886412..3887377	+	966	WP_000054520.1	hypothetical protein	-
FOV95_RS18730	3887384..3888124	+	741	WP_000790459.1	ATP-binding protein	-
FOV95_RS18735	3888154..3888915	+	762	WP_064506729.1	DUF1627 domain-containing protein	-
FOV95_RS18740	3888948..3889229	+	282	WP_072094476.1	DNA-binding protein	-
FOV95_RS18745	3889226..3889531	+	306	WP_053294093.1	DUF4406 domain-containing protein	-
FOV95_RS18750	3889679..3889861	+	183	WP_022581296.1	hypothetical protein	-
FOV95_RS23650	3889854..3890030	+	177	WP_000753060.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3878749..3924187	45438

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11014.71 Da
• Isoelectric Point: 6.2118

>T129137 WP_001444087.1 NZ_CP041749:c3884911-3884624 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVATLSIE
IVSVVHARRQFPKQN

Nucleotide

• Length: 288 bp

>T129137 NZ_CP041749:c3884911-3884624 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGGTGTGTGCTGCCGTTATCCGAACACCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCTCACCCTAACTATATAATTCTTTACCGTGTAGCCACTTTAAGCATTGAG
ATCGTGAGTGTAGTACACGCCAGACGCCAATTCCCCAAGCAGAACTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7249.25 Da
• Isoelectric Point: 8.6832

>AT129137 WP_001090455.1 NZ_CP041749:c3885103-3884915 [Escherichia coli]
MNTALSPMVSEFETIEQENSYNEWLRAKVAASLANPRPAIPHDEVERRMAERFAKMRKERSK

Nucleotide

• Length: 189 bp

>AT129137 NZ_CP041749:c3885103-3884915 [Escherichia coli]
ATGAATACGGCCCTTTCACCAATGGTTTCTGAGTTCGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAGCGAGCCTTGCAAATCCGCGCCCAGCAATTCCCCATGACGAGGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGTAAGTAG

Structures

Toxin

• AlphaFold DB: A0A234Y3J1

Antitoxin

• AlphaFold DB: A0A234Y267