Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3790092..3790890 Replicon chromosome
Accession NZ_CP041749
Organism Escherichia coli strain NCCP 15955

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0V7WHV8
Locus tag FOV95_RS18185 Protein ID WP_001506713.1
Coordinates 3790513..3790890 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag FOV95_RS18180 Protein ID WP_001280952.1
Coordinates 3790092..3790466 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOV95_RS18140 3785170..3786075 + 906 WP_021497799.1 yjcZ-like family protein -
FOV95_RS18145 3786072..3787142 + 1071 WP_000102643.1 patatin-like phospholipase family protein -
FOV95_RS18150 3787289..3787411 + 123 Protein_3520 DUF905 family protein -
FOV95_RS18155 3787511..3788329 + 819 WP_001234621.1 DUF945 domain-containing protein -
FOV95_RS18160 3788329..3788574 + 246 WP_000680583.1 hypothetical protein -
FOV95_RS18165 3788668..3789147 + 480 WP_041124081.1 antirestriction protein -
FOV95_RS18170 3789163..3789639 + 477 WP_041124082.1 RadC family protein -
FOV95_RS18175 3789708..3789929 + 222 WP_041124083.1 DUF987 domain-containing protein -
FOV95_RS18180 3790092..3790466 + 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FOV95_RS18185 3790513..3790890 + 378 WP_001506713.1 TA system toxin CbtA family protein Toxin
FOV95_RS18190 3790887..3791375 + 489 WP_001470575.1 hypothetical protein -
FOV95_RS18195 3791387..3791584 + 198 WP_000839282.1 DUF957 domain-containing protein -
FOV95_RS18200 3791669..3792509 + 841 Protein_3530 DUF4942 domain-containing protein -
FOV95_RS18210 3792980..3793918 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
FOV95_RS18215 3793973..3794710 + 738 WP_000283667.1 zinc-binding phosphatase -
FOV95_RS18220 3794734..3795288 + 555 WP_001001921.1 molecular chaperone YcdY -
FOV95_RS18225 3795390..3795881 + 492 WP_001300785.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 3788668..3801445 12777


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.26 Da        Isoelectric Point: 7.8045

>T129136 WP_001506713.1 NZ_CP041749:3790513-3790890 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR

Download         Length: 378 bp

>T129136 NZ_CP041749:3790513-3790890 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCCCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACATAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT129136 WP_001280952.1 NZ_CP041749:3790092-3790466 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT129136 NZ_CP041749:3790092-3790466 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGAAATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGGCACAGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V7WHV8

Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References