Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2385826..2386658 Replicon chromosome
Accession NZ_CP041749
Organism Escherichia coli strain NCCP 15955

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag FOV95_RS11555 Protein ID WP_000854753.1
Coordinates 2386284..2386658 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag FOV95_RS11550 Protein ID WP_001315620.1
Coordinates 2385826..2386194 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOV95_RS11510 2381175..2381306 - 132 Protein_2228 IS3 family transposase -
FOV95_RS11515 2381588..2381788 + 201 WP_000823256.1 hypothetical protein -
FOV95_RS11520 2381997..2382122 - 126 Protein_2230 hemolysin activation protein -
FOV95_RS11525 2382879..2383076 + 198 WP_000179417.1 autotransporter domain-containing protein -
FOV95_RS11530 2383197..2384732 + 1536 WP_000939409.1 hypothetical protein -
FOV95_RS11535 2384717..2384887 + 171 Protein_2233 antirestriction protein -
FOV95_RS11540 2384903..2385379 + 477 WP_001186774.1 RadC family protein -
FOV95_RS11545 2385442..2385663 + 222 WP_000692345.1 DUF987 domain-containing protein -
FOV95_RS11550 2385826..2386194 + 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FOV95_RS11555 2386284..2386658 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
FOV95_RS11560 2386655..2387143 + 489 WP_000777547.1 hypothetical protein -
FOV95_RS11565 2387155..2387352 + 198 WP_000839281.1 DUF957 domain-containing protein -
FOV95_RS11575 2388891..2389025 + 135 Protein_2241 transcriptional regulator -
FOV95_RS11580 2389969..2390619 + 651 WP_001037966.1 HNH endonuclease -
FOV95_RS11585 2390627..2391607 - 981 WP_000991415.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimB / fimE 2355689..2396646 40957


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T129132 WP_000854753.1 NZ_CP041749:2386284-2386658 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T129132 NZ_CP041749:2386284-2386658 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT129132 WP_001315620.1 NZ_CP041749:2385826-2386194 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT129132 NZ_CP041749:2385826-2386194 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References