Detailed information of TA system TA129131

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2107684..2108482
• Replicon: chromosome
• Accession: NZ_CP041749
• Organism: Escherichia coli strain NCCP 15955

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FOV95_RS10205
• Protein ID: WP_040076706.1
• Coordinates: 2107684..2108061 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A234XUW5
• Locus tag: FOV95_RS10210
• Protein ID: WP_024175300.1
• Coordinates: 2108108..2108482 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOV95_RS10175	2102961..2104499	-	1539	WP_001187173.1	lysine decarboxylation/transport transcriptional activator CadC	-
FOV95_RS10180	2105381..2105707	-	327	WP_000779483.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FOV95_RS10185	2105704..2105967	-	264	WP_001143297.1	type II toxin-antitoxin system ParD family antitoxin	-
FOV95_RS10190	2106039..2106905	-	867	WP_000014510.1	DUF4942 domain-containing protein	-
FOV95_RS10195	2106990..2107187	-	198	WP_000839256.1	DUF957 domain-containing protein	-
FOV95_RS10200	2107199..2107687	-	489	WP_000761662.1	hypothetical protein	-
FOV95_RS10205	2107684..2108061	-	378	WP_040076706.1	TA system toxin CbtA family protein	Toxin
FOV95_RS10210	2108108..2108482	-	375	WP_024175300.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FOV95_RS10215	2108645..2108866	-	222	WP_000692358.1	DUF987 domain-containing protein	-
FOV95_RS10220	2108929..2109405	-	477	WP_001186727.1	RadC family protein	-
FOV95_RS10225	2109421..2109906	-	486	WP_000214386.1	antirestriction protein	-
FOV95_RS10230	2109996..2110814	-	819	WP_159394860.1	DUF945 domain-containing protein	-
FOV95_RS10235	2110904..2111137	-	234	WP_001117568.1	DUF905 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2095473..2141927	46454

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14180.10 Da
• Isoelectric Point: 7.2920

>T129131 WP_040076706.1 NZ_CP041749:c2108061-2107684 [Escherichia coli]
MKTLSDTHVREASRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAQQ

Nucleotide

• Length: 378 bp

>T129131 NZ_CP041749:c2108061-2107684 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13664.42 Da
• Isoelectric Point: 6.4757

>AT129131 WP_024175300.1 NZ_CP041749:c2108482-2108108 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVKPCFGARLVQEGNRLHYLADRAGISGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHSVTLYAKGLTCEADTLGSCGYVYLTVYPTPATATTS

Nucleotide

• Length: 375 bp

>AT129131 NZ_CP041749:c2108482-2108108 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAA
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGCGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATTCCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCAACCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A234XUW5