Detailed information of TA system TA129125

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 822280..823112
• Replicon: chromosome
• Accession: NZ_CP041749
• Organism: Escherichia coli strain NCCP 15955

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: FOV95_RS04115
• Protein ID: WP_000854816.1
• Coordinates: 822738..823112 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FOV95_RS04110
• Protein ID: WP_001285402.1
• Coordinates: 822280..822648 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOV95_RS04080	818917..819372	+	456	WP_000581504.1	hypothetical protein	-
FOV95_RS23560	819493..819704	-	212	Protein_791	hypothetical protein	-
FOV95_RS04090	819775..820593	+	819	WP_001234639.1	DUF945 domain-containing protein	-
FOV95_RS04095	820856..821335	+	480	WP_019842849.1	antirestriction protein	-
FOV95_RS04100	821351..821827	+	477	WP_001747787.1	RadC family protein	-
FOV95_RS04105	821896..822117	+	222	WP_000692323.1	DUF987 domain-containing protein	-
FOV95_RS04110	822280..822648	+	369	WP_001285402.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FOV95_RS04115	822738..823112	+	375	WP_000854816.1	type IV toxin-antitoxin system toxin CbtA	Toxin
FOV95_RS04120	823109..823600	+	492	WP_000976865.1	hypothetical protein	-
FOV95_RS04125	823620..823817	+	198	WP_000772027.1	DUF957 domain-containing protein	-
FOV95_RS04130	823902..824744	+	843	WP_001274564.1	DUF4942 domain-containing protein	-
FOV95_RS04135	825025..825561	-	537	WP_000942785.1	GspM family type II secretion system protein YghD	-
FOV95_RS04140	825563..827008	-	1446	WP_000933249.1	inorganic phosphate transporter PitB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14045.05 Da
• Isoelectric Point: 9.1493

>T129125 WP_000854816.1 NZ_CP041749:822738-823112 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLSRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Nucleotide

• Length: 375 bp

>T129125 NZ_CP041749:822738-823112 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCGCGTCCGTCTCCTGTTGAAATCTGGCAGACACTGCTGTC
CCGCCTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13883.62 Da
• Isoelectric Point: 6.3165

>AT129125 WP_001285402.1 NZ_CP041749:822280-822648 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELILTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT129125 NZ_CP041749:822280-822648 [Escherichia coli]
GTGTCAGACACGCACCATGAGACAAATTATCCCGACGACTATAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCATAAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATACTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGACTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA