Detailed information of TA system TA129122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 2763304..2763820
• Replicon: chromosome
• Accession: NZ_CP041745
• Organism: Paraburkholderia megapolitana strain LMG 23650

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: FNZ07_RS25575
• Protein ID: WP_091014375.1
• Coordinates: 2763304..2763585 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FNZ07_RS25580
• Protein ID: WP_091014378.1
• Coordinates: 2763575..2763820 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNZ07_RS25555	2758471..2759847	-	1377	WP_091014366.1	cytochrome P450	-
FNZ07_RS25560	2759832..2760911	-	1080	WP_091014369.1	alpha-hydroxy-acid oxidizing protein	-
FNZ07_RS25565	2760930..2762486	-	1557	WP_091014372.1	NAD(P)-binding domain-containing protein	-
FNZ07_RS25575	2763304..2763585	-	282	WP_091014375.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FNZ07_RS25580	2763575..2763820	-	246	WP_091014378.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FNZ07_RS25585	2764066..2764842	+	777	WP_091014381.1	exodeoxyribonuclease III	-
FNZ07_RS25590	2764937..2766463	-	1527	WP_091014384.1	nitrogen regulation protein NR(I)	-
FNZ07_RS25595	2766498..2767640	-	1143	WP_091014387.1	PAS domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10960.56 Da
• Isoelectric Point: 10.0977

>T129122 WP_091014375.1 NZ_CP041745:c2763585-2763304 [Paraburkholderia megapolitana]
MPYELDFAESAAREWGKLDSTVKRQFAKKPTERLENPHVPSSRLHDMKDCYKIKLRASGYRLVYRVEDRTVTVFVIAVGK
REKNRVYVDAQDR

Nucleotide

• Length: 282 bp

>T129122 NZ_CP041745:c2763585-2763304 [Paraburkholderia megapolitana]
ATGCCGTATGAACTCGATTTCGCCGAAAGTGCAGCGAGGGAATGGGGGAAGCTGGATTCGACGGTCAAGAGGCAGTTCGC
CAAAAAGCCGACGGAGCGCCTTGAGAATCCGCATGTTCCATCTTCTCGTCTGCACGACATGAAGGACTGCTACAAGATCA
AGCTTCGTGCAAGCGGATATCGTCTAGTCTACCGGGTCGAGGATCGAACGGTTACGGTGTTCGTCATCGCCGTTGGCAAG
CGGGAGAAGAACAGGGTGTATGTCGACGCGCAAGACAGATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8942.35 Da
• Isoelectric Point: 4.7361

>AT129122 WP_091014378.1 NZ_CP041745:c2763820-2763575 [Paraburkholderia megapolitana]
MEAILADQSVGISELKANPTAVVEQAHGQPVALLNRNKPIAYIVPAARWEKLLDMLDDIQLAQIVKERESEPRVKVDINA
V

Nucleotide

• Length: 246 bp

>AT129122 NZ_CP041745:c2763820-2763575 [Paraburkholderia megapolitana]
ATGGAAGCCATTCTTGCAGATCAATCGGTTGGGATTTCCGAGCTGAAGGCGAACCCGACCGCCGTCGTGGAACAGGCGCA
CGGCCAACCGGTTGCGCTGCTGAATCGAAACAAACCGATCGCCTATATCGTGCCTGCCGCGCGCTGGGAAAAACTGCTCG
ACATGCTCGACGACATCCAGCTCGCCCAGATCGTGAAGGAGCGTGAGAGCGAGCCGCGGGTCAAGGTGGACATCAATGCC
GTATGA