Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2710190..2710773 Replicon chromosome
Accession NZ_CP041745
Organism Paraburkholderia megapolitana strain LMG 23650

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FNZ07_RS25340 Protein ID WP_091014232.1
Coordinates 2710393..2710773 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FNZ07_RS25335 Protein ID WP_091014770.1
Coordinates 2710190..2710396 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNZ07_RS25320 2706158..2707262 + 1105 WP_143098098.1 peptide chain release factor 2 -
FNZ07_RS25325 2707412..2708938 + 1527 WP_091014225.1 lysine--tRNA ligase -
FNZ07_RS25330 2709245..2709931 + 687 WP_091014229.1 glycine zipper 2TM domain-containing protein -
FNZ07_RS25335 2710190..2710396 + 207 WP_091014770.1 DUF2191 domain-containing protein Antitoxin
FNZ07_RS25340 2710393..2710773 + 381 WP_091014232.1 PIN domain-containing protein Toxin
FNZ07_RS25345 2710848..2711045 - 198 WP_091014236.1 Fe-S cluster assembly protein IscX -
FNZ07_RS25350 2711061..2711402 - 342 WP_091014239.1 ISC system 2Fe-2S type ferredoxin -
FNZ07_RS25355 2711553..2713424 - 1872 WP_091014244.1 Fe-S protein assembly chaperone HscA -
FNZ07_RS25360 2713498..2714025 - 528 WP_091014248.1 Fe-S protein assembly co-chaperone HscB -
FNZ07_RS25365 2714142..2714465 - 324 WP_091014251.1 iron-sulfur cluster assembly protein IscA -
FNZ07_RS25370 2714567..2714983 - 417 WP_091014254.1 Fe-S cluster assembly scaffold IscU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14335.62 Da        Isoelectric Point: 6.8360

>T129121 WP_091014232.1 NZ_CP041745:2710393-2710773 [Paraburkholderia megapolitana]
MNVLIDTSVWVDHFRRSNAELQQLLRVDVCVTHPLVVLELTCGTPPEPRAQVLSDIALLRQTRLATHAEVAGLIERERLY
GLGCGAVDCTLLASTLLTPDTRFWTLDQRLRRLTERFDVCYVPRVH

Download         Length: 381 bp

>T129121 NZ_CP041745:2710393-2710773 [Paraburkholderia megapolitana]
ATGAACGTCCTGATCGATACCTCGGTCTGGGTGGATCATTTCCGGCGCTCCAACGCCGAGCTGCAGCAGCTTTTGCGAGT
TGATGTTTGCGTCACGCACCCCCTGGTTGTCCTCGAACTGACCTGCGGCACACCGCCGGAGCCGCGCGCACAGGTACTCA
GCGATATCGCCCTGCTACGCCAGACGCGACTGGCCACACACGCCGAGGTGGCGGGCCTGATCGAGCGTGAGCGTTTATAT
GGACTGGGATGTGGCGCGGTGGACTGCACCTTGCTGGCGTCGACGCTATTGACGCCGGACACGCGATTCTGGACGCTGGA
CCAGCGTCTCAGACGGCTGACCGAACGGTTCGATGTGTGCTACGTGCCGCGTGTGCACTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7421.47 Da        Isoelectric Point: 7.0116

>AT129121 WP_091014770.1 NZ_CP041745:2710190-2710396 [Paraburkholderia megapolitana]
VRTTVTVDDLLYTRALELAEPGISAADLFREALETFVRIQAGKRLAALGGHAPEMAEIARRRPDGTSR

Download         Length: 207 bp

>AT129121 NZ_CP041745:2710190-2710396 [Paraburkholderia megapolitana]
GTGCGAACTACCGTCACCGTCGACGACCTGCTCTACACGCGTGCCCTCGAACTCGCTGAACCGGGAATCAGCGCAGCGGA
TCTCTTCCGCGAAGCCCTGGAGACGTTCGTCCGGATCCAGGCTGGCAAGCGCCTCGCCGCGCTCGGTGGCCACGCACCCG
AGATGGCCGAGATTGCGCGGCGGCGTCCGGATGGGACGTCCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References