Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 34588..35225 Replicon plasmid unnamed1
Accession NZ_CP041744
Organism Paraburkholderia megapolitana strain LMG 23650

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FNZ07_RS12915 Protein ID WP_091020351.1
Coordinates 34824..35225 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FNZ07_RS12910 Protein ID WP_091020349.1
Coordinates 34588..34824 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNZ07_RS12880 30482..31039 - 558 WP_143098183.1 hypothetical protein -
FNZ07_RS12885 31433..32110 - 678 WP_091020343.1 GNAT family N-acetyltransferase -
FNZ07_RS12890 32490..33368 - 879 WP_170275746.1 LysR family transcriptional regulator -
FNZ07_RS12895 33458..33757 + 300 WP_091020347.1 hypothetical protein -
FNZ07_RS12905 34072..34425 + 354 Protein_32 tyrosine-type recombinase/integrase -
FNZ07_RS12910 34588..34824 + 237 WP_091020349.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FNZ07_RS12915 34824..35225 + 402 WP_091020351.1 type II toxin-antitoxin system VapC family toxin Toxin
FNZ07_RS33615 35249..35422 + 174 WP_170275747.1 hypothetical protein -
FNZ07_RS12920 35432..35929 + 498 WP_143098185.1 hypothetical protein -
FNZ07_RS12925 36529..37164 + 636 WP_091020358.1 GIY-YIG nuclease family protein -
FNZ07_RS12930 37173..37391 + 219 WP_091020361.1 hypothetical protein -
FNZ07_RS12935 37702..38127 + 426 WP_091020390.1 hypothetical protein -
FNZ07_RS12940 38404..38841 + 438 WP_091020363.1 hypothetical protein -
FNZ07_RS12945 39055..39459 - 405 WP_091020365.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125785 125785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14977.27 Da        Isoelectric Point: 5.7642

>T129119 WP_091020351.1 NZ_CP041744:34824-35225 [Paraburkholderia megapolitana]
MPRFMLDTNMCIYLMKNQPERVAKRFAECFVGDVVMSAITYAELEYGVVVSDNRAKERRNLAALIEDIPVTPFDAAAAVA
YGPIREATRERKKDHLDKLIAAHAVALDVVLVTNNTKDFTSYPGVKLENWLND

Download         Length: 402 bp

>T129119 NZ_CP041744:34824-35225 [Paraburkholderia megapolitana]
ATGCCGCGCTTCATGCTCGACACCAATATGTGCATCTACCTGATGAAGAACCAGCCTGAGCGCGTAGCAAAGCGTTTCGC
GGAGTGCTTCGTCGGTGACGTGGTGATGTCCGCTATCACATATGCCGAGCTTGAATACGGCGTCGTGGTTTCTGACAACC
GGGCGAAAGAGCGGCGGAACCTCGCCGCATTGATTGAGGACATTCCGGTGACTCCGTTTGATGCGGCGGCGGCAGTAGCC
TATGGTCCGATTCGTGAGGCTACGCGGGAGCGCAAGAAGGACCACTTAGACAAGTTGATCGCCGCACATGCGGTTGCGCT
CGACGTTGTGCTTGTCACGAACAACACAAAAGACTTCACCAGCTATCCGGGTGTCAAGCTCGAAAACTGGCTGAACGATT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8944.13 Da        Isoelectric Point: 6.3677

>AT129119 WP_091020349.1 NZ_CP041744:34588-34824 [Paraburkholderia megapolitana]
MQTTRVFRNGNSQAVRIPADLAYERSDVELEIERVGDEIRIRPARRPLIGVLKKFARFGPDFMAEGRGEQEQAEREGL

Download         Length: 237 bp

>AT129119 NZ_CP041744:34588-34824 [Paraburkholderia megapolitana]
ATGCAGACGACTCGAGTTTTCAGGAATGGCAACTCTCAGGCCGTTCGTATCCCCGCCGATCTTGCCTATGAGCGCAGCGA
TGTTGAACTTGAAATTGAGCGCGTAGGTGACGAAATCCGTATTCGCCCTGCCCGCCGACCGCTGATTGGCGTGCTCAAGA
AGTTTGCCAGGTTCGGTCCCGACTTCATGGCTGAGGGGCGTGGTGAGCAGGAGCAAGCTGAACGTGAGGGCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References