Detailed information of TA system TA129118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 850541..851064
• Replicon: chromosome
• Accession: NZ_CP041743
• Organism: Paraburkholderia megapolitana strain LMG 23650

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FNZ07_RS03600
• Protein ID: WP_211367868.1
• Coordinates: 850541..850795 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FNZ07_RS03605
• Protein ID: WP_091008583.1
• Coordinates: 850804..851064 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNZ07_RS03580	845606..846301	+	696	WP_170275658.1	helix-turn-helix transcriptional regulator	-
FNZ07_RS03585	847227..848033	+	807	WP_091008570.1	hypothetical protein	-
FNZ07_RS03590	848542..849051	+	510	WP_091008573.1	DoxX family protein	-
FNZ07_RS03595	849105..850367	-	1263	WP_091008577.1	multidrug effflux MFS transporter	-
FNZ07_RS03600	850541..850795	-	255	WP_211367868.1	Txe/YoeB family addiction module toxin	Toxin
FNZ07_RS03605	850804..851064	-	261	WP_091008583.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FNZ07_RS03610	851245..852315	-	1071	WP_091008585.1	porin	-
FNZ07_RS03615	852315..854768	-	2454	WP_091008587.1	glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase	-
FNZ07_RS03620	854874..855977	-	1104	WP_091008589.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10045.47 Da
• Isoelectric Point: 7.9846

>T129118 WP_211367868.1 NZ_CP041743:c850795-850541 [Paraburkholderia megapolitana]
MNVMWTAEAWDDYVYWQGQDKKTLRRINQLIKEMQRTPFEGIGKPEPLKENLAGLWSRRIDDTNRLVYEVAGPQLNVISC
RYHY

Nucleotide

• Length: 255 bp

>T129118 NZ_CP041743:c850795-850541 [Paraburkholderia megapolitana]
TTGAACGTCATGTGGACTGCAGAGGCGTGGGACGACTATGTCTACTGGCAGGGACAGGACAAGAAGACACTCAGGCGCAT
CAATCAACTCATCAAGGAAATGCAACGCACGCCGTTTGAGGGAATCGGTAAGCCCGAGCCGTTAAAGGAAAACTTGGCGG
GTCTCTGGTCACGCCGAATCGACGACACGAATCGCCTGGTCTACGAAGTCGCCGGCCCGCAACTCAACGTCATCTCGTGT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9627.01 Da
• Isoelectric Point: 7.3193

>AT129118 WP_091008583.1 NZ_CP041743:c851064-850804 [Paraburkholderia megapolitana]
MRTIPFTDARANLKSVIDQVVDDMDVTLITRRDSPNAIVMSQSHYDSLMETVHLLRSPANVAHLERSIAQARAGKVKPRK
LVEGDE

Nucleotide

• Length: 261 bp

>AT129118 NZ_CP041743:c851064-850804 [Paraburkholderia megapolitana]
ATGCGCACCATTCCGTTTACCGACGCACGCGCGAACTTAAAAAGCGTCATCGATCAGGTGGTCGACGACATGGACGTTAC
GCTCATCACCCGGCGCGACTCGCCCAACGCGATCGTCATGTCCCAGTCGCATTACGACAGCCTGATGGAAACCGTTCACC
TGCTGCGCTCCCCGGCCAACGTTGCGCATCTGGAGCGGTCGATCGCGCAAGCACGGGCGGGCAAGGTCAAGCCCCGTAAG
CTGGTTGAAGGCGACGAATGA