Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 505044..505697 Replicon chromosome
Accession NZ_CP041743
Organism Paraburkholderia megapolitana strain LMG 23650

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FNZ07_RS02105 Protein ID WP_091007785.1
Coordinates 505281..505697 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FNZ07_RS02100 Protein ID WP_091007783.1
Coordinates 505044..505256 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FNZ07_RS02080 500815..501795 - 981 WP_091007768.1 SDR family oxidoreductase -
FNZ07_RS02085 501815..502603 - 789 WP_091007771.1 hydroxypyruvate isomerase family protein -
FNZ07_RS02090 502658..503806 - 1149 WP_091007775.1 hypothetical protein -
FNZ07_RS02095 503843..504979 - 1137 WP_091007780.1 hypothetical protein -
FNZ07_RS02100 505044..505256 - 213 WP_091007783.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FNZ07_RS02105 505281..505697 - 417 WP_091007785.1 type II toxin-antitoxin system VapC family toxin Toxin
FNZ07_RS02110 505684..505920 - 237 WP_091007788.1 DNA-binding protein -
FNZ07_RS02115 506211..507854 + 1644 WP_091007791.1 hypothetical protein -
FNZ07_RS02120 508016..509290 + 1275 WP_091007793.1 MFS transporter -
FNZ07_RS02125 509300..509668 - 369 WP_091007796.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15482.75 Da        Isoelectric Point: 6.4845

>T129116 WP_091007785.1 NZ_CP041743:c505697-505281 [Paraburkholderia megapolitana]
VYLVDTNIVSEIRKKERCNKGVRAFFRQAVKSDIDLYLSVVTIGELRRGVEIVRHRGDVAQAASLEAWLTAVLNEFAQNI
LPVDEDIGQLWGRLRVPHPEHALDKLIAATGLIHDLTVVTRNVDDFSPTGVRVLNPFD

Download         Length: 417 bp

>T129116 NZ_CP041743:c505697-505281 [Paraburkholderia megapolitana]
GTGTATTTGGTTGATACCAACATCGTGAGCGAAATAAGAAAGAAAGAGCGCTGCAATAAAGGCGTGCGCGCTTTCTTCCG
GCAAGCAGTGAAGTCGGATATCGATCTGTATCTGTCCGTGGTCACCATTGGTGAACTGAGGCGTGGCGTCGAGATAGTTC
GACATCGGGGAGATGTGGCGCAAGCCGCATCCCTCGAGGCGTGGTTGACGGCGGTGCTCAACGAGTTCGCGCAGAACATT
CTCCCGGTGGACGAGGACATTGGGCAATTGTGGGGGAGACTACGCGTACCGCACCCGGAGCATGCGTTGGATAAGCTGAT
CGCGGCGACGGGGCTGATTCACGATCTGACTGTCGTGACGCGGAACGTCGATGATTTTTCGCCCACGGGGGTTCGTGTAT
TGAACCCGTTTGATTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7766.96 Da        Isoelectric Point: 10.9288

>AT129116 WP_091007783.1 NZ_CP041743:c505256-505044 [Paraburkholderia megapolitana]
MRTTVTIDDDLIERAQAYTGLEEKTALVREALKALIEREAAKRLANLGGSQKGIKGAPRRRRDVLPAAHR

Download         Length: 213 bp

>AT129116 NZ_CP041743:c505256-505044 [Paraburkholderia megapolitana]
ATGCGCACTACCGTTACTATCGATGACGATTTGATCGAGAGAGCCCAAGCCTATACAGGCTTGGAGGAAAAAACAGCACT
TGTGCGCGAAGCGCTCAAGGCATTGATCGAGCGTGAAGCCGCAAAACGACTCGCCAATCTTGGCGGTAGCCAGAAAGGAA
TCAAGGGAGCGCCGCGTCGCCGGCGCGATGTGTTGCCAGCAGCACACCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References