Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1106173..1106793 Replicon chromosome
Accession NZ_CP041733
Organism Enterobacter hormaechei subsp. steigerwaltii strain ME-1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag FO617_RS05295 Protein ID WP_015571250.1
Coordinates 1106173..1106391 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag FO617_RS05300 Protein ID WP_006809850.1
Coordinates 1106419..1106793 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO617_RS05265 1102185..1102445 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
FO617_RS05270 1102448..1102588 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
FO617_RS05275 1102585..1103295 - 711 WP_032670463.1 GNAT family N-acetyltransferase -
FO617_RS05280 1103397..1104857 + 1461 WP_126804881.1 PLP-dependent aminotransferase family protein -
FO617_RS05285 1104829..1105296 - 468 WP_023296041.1 hypothetical protein -
FO617_RS05290 1105413..1105964 - 552 WP_015571251.1 maltose O-acetyltransferase -
FO617_RS05295 1106173..1106391 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
FO617_RS05300 1106419..1106793 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
FO617_RS05305 1107304..1110450 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit -
FO617_RS05310 1110473..1111666 - 1194 WP_144427690.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T129070 WP_015571250.1 NZ_CP041733:c1106391-1106173 [Enterobacter hormaechei subsp. steigerwaltii]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T129070 NZ_CP041733:c1106391-1106173 [Enterobacter hormaechei subsp. steigerwaltii]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTTGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT129070 WP_006809850.1 NZ_CP041733:c1106793-1106419 [Enterobacter hormaechei subsp. steigerwaltii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT129070 NZ_CP041733:c1106793-1106419 [Enterobacter hormaechei subsp. steigerwaltii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTCAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References