Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 581535..582248 Replicon chromosome
Accession NZ_CP041733
Organism Enterobacter hormaechei subsp. steigerwaltii strain ME-1

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag FO617_RS02805 Protein ID WP_144427656.1
Coordinates 581910..582248 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag FO617_RS02800 Protein ID WP_144427655.1
Coordinates 581535..581885 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO617_RS02760 577137..577865 + 729 WP_144427649.1 DUF3944 domain-containing protein -
FO617_RS02765 577927..578604 + 678 WP_071067386.1 WYL domain-containing protein -
FO617_RS02770 578712..579122 + 411 WP_144428038.1 hypothetical protein -
FO617_RS02775 579177..579536 + 360 WP_144427650.1 hypothetical protein -
FO617_RS02780 579617..579829 + 213 WP_144427651.1 hypothetical protein -
FO617_RS02785 579940..580761 + 822 WP_144427652.1 DUF945 domain-containing protein -
FO617_RS02790 580797..581279 + 483 WP_144427653.1 DNA repair protein RadC -
FO617_RS02795 581293..581514 + 222 WP_144427654.1 DUF987 domain-containing protein -
FO617_RS02800 581535..581885 + 351 WP_144427655.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FO617_RS02805 581910..582248 + 339 WP_144427656.1 TA system toxin CbtA family protein Toxin
FO617_RS02810 582363..583196 + 834 WP_144427657.1 DUF4942 domain-containing protein -
FO617_RS02815 583273..583521 + 249 WP_000535213.1 ribbon-helix-helix domain-containing protein -
FO617_RS02820 583525..583800 + 276 Protein_538 type II toxin-antitoxin system RelE/ParE family toxin -
FO617_RS02825 583915..584712 + 798 WP_144427658.1 helix-turn-helix domain-containing protein -
FO617_RS02830 584844..585710 - 867 WP_126804992.1 HNH endonuclease -
FO617_RS02835 586012..586485 + 474 WP_072203889.1 SymE family type I addiction module toxin -
FO617_RS02840 586563..586934 - 372 WP_144427659.1 DUF1493 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 552996..597204 44208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12834.71 Da        Isoelectric Point: 8.0324

>T129069 WP_144427656.1 NZ_CP041733:581910-582248 [Enterobacter hormaechei subsp. steigerwaltii]
MKTFPANQRVAKPCPPLVLVWQTLLTRLLEQHYGLTLNDTPFSDESVIQEHIDAGITLADAVNFLVEKYELVRIDRRGFS
WQEQSPYLRAVDILRARQATGLLRQGNNLSTR

Download         Length: 339 bp

>T129069 NZ_CP041733:581910-582248 [Enterobacter hormaechei subsp. steigerwaltii]
ATGAAAACTTTTCCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCACTAGTACTTGTCTGGCAAACGTTGCTTACGCG
CCTACTGGAGCAACACTATGGCCTAACGCTGAACGACACGCCGTTCAGTGATGAAAGCGTTATTCAGGAGCATATCGACG
CCGGTATTACGCTGGCGGATGCCGTTAACTTTCTGGTGGAAAAGTACGAGCTGGTTCGTATCGATCGCAGGGGATTTAGC
TGGCAGGAACAATCGCCTTATCTGCGGGCTGTAGACATTTTGCGGGCGCGACAGGCAACTGGTCTGTTACGACAAGGCAA
TAATCTTTCGACACGCTGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13342.10 Da        Isoelectric Point: 5.9583

>AT129069 WP_144427655.1 NZ_CP041733:581535-581885 [Enterobacter hormaechei subsp. steigerwaltii]
MQNKRKIAVQDIAEPWWGLRSDFSPCFSARLVQEDNQLHYLADRASFNGQFSDADLRHLDLAFPVLMKQLELVLTSGELN
PRHQHCVTLYHNELTCEADTLGSCGYVYLAIYPTQR

Download         Length: 351 bp

>AT129069 NZ_CP041733:581535-581885 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCAGAATAAAAGAAAGATCGCAGTTCAGGATATTGCTGAACCGTGGTGGGGACTCCGAAGCGATTTCTCACCGTGTTT
TAGTGCCCGTCTGGTACAGGAGGATAACCAGTTGCATTACCTGGCTGACCGCGCCAGCTTTAACGGTCAGTTCAGCGATG
CGGATTTACGCCATCTCGACTTGGCTTTTCCTGTACTGATGAAACAGCTAGAACTGGTGCTCACCAGTGGTGAGCTTAAT
CCACGGCACCAGCACTGCGTTACGCTGTATCACAACGAACTGACCTGTGAAGCGGATACGCTTGGTAGCTGTGGCTACGT
TTATCTCGCTATCTATCCCACCCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References