Detailed information of TA system TA129056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1118119..1118596
• Replicon: chromosome
• Accession: NZ_CP041730
• Organism: Chitinimonas arctica strain R3-44

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: FNU76_RS04875
• Protein ID: WP_143856660.1
• Coordinates: 1118119..1118388 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: FNU76_RS04880
• Protein ID: WP_144280585.1
• Coordinates: 1118372..1118596 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FNU76_RS04865	1116340..1116825	+	486	WP_143856659.1	hypothetical protein	-
FNU76_RS04870	1117226..1118083	+	858	WP_144280584.1	transposase	-
FNU76_RS04875	1118119..1118388	-	270	WP_143856660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FNU76_RS04880	1118372..1118596	-	225	WP_144280585.1	TraY domain-containing protein	Antitoxin
FNU76_RS04885	1119069..1119359	+	291	WP_143856661.1	helix-turn-helix domain-containing protein	-
FNU76_RS04890	1119480..1119641	+	162	WP_143856662.1	DNA-binding protein	-
FNU76_RS04895	1119638..1120003	+	366	WP_143856663.1	hypothetical protein	-
FNU76_RS04900	1120165..1120833	-	669	WP_143856664.1	site-2 protease family protein	-
FNU76_RS04905	1120979..1121665	-	687	WP_143856665.1	site-2 protease family protein	-
FNU76_RS04910	1121704..1122228	-	525	WP_143856666.1	CPBP family intramembrane metalloprotease	-
FNU76_RS04915	1122225..1122848	-	624	WP_143856667.1	threonylcarbamoyl-AMP synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Protein of unknown function DUF6290 (3-70)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10254.88 Da
• Isoelectric Point: 9.9850

>T129056 WP_143856660.1 NZ_CP041730:c1118388-1118119 [Chitinimonas arctica]
MAWRIEVTDSALKQLGKLDRPVAQRIRSFLLDRLATLDDPRSIGEALKGGELGELWKYRVGDYRIISSIEDGALKILVVR
IDNRREVYR

Nucleotide

• Length: 270 bp

>T129056 NZ_CP041730:c1118388-1118119 [Chitinimonas arctica]
TTGGCCTGGCGGATTGAAGTGACCGATAGCGCCCTGAAACAGCTTGGCAAGCTGGATCGGCCGGTTGCCCAGCGTATCCG
CAGCTTCCTGCTGGATCGATTGGCGACCTTGGATGACCCGCGCTCAATCGGTGAAGCGCTCAAAGGCGGTGAACTGGGCG
AGCTCTGGAAGTACCGGGTAGGTGATTACCGCATCATCAGCAGCATCGAGGATGGTGCGTTGAAAATTCTGGTGGTGCGG
ATTGACAACCGGCGCGAGGTGTATCGCTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8606.77 Da
• Isoelectric Point: 4.5052

>AT129056 WP_144280585.1 NZ_CP041730:c1118596-1118372 [Chitinimonas arctica]
MLAIRLPQDIETRLENLAQRTGRTKSFYVREAIMEHLEDLEDLYLAEQVLRRVRSGEEQTYTLAEVEAKLGLAD

Nucleotide

• Length: 225 bp

>AT129056 NZ_CP041730:c1118596-1118372 [Chitinimonas arctica]
ATGCTGGCCATCCGTCTCCCGCAAGACATCGAGACCCGCCTGGAAAATCTGGCGCAGCGCACTGGGCGCACCAAGAGCTT
CTATGTTCGCGAAGCGATCATGGAGCACTTGGAAGACCTGGAAGACCTCTACCTGGCCGAGCAGGTACTGCGGCGCGTGC
GCAGTGGCGAGGAGCAGACTTACACCCTGGCAGAAGTAGAGGCAAAGCTTGGCCTGGCGGATTGA