Detailed information of TA system TA129051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2479155..2479684
• Replicon: chromosome
• Accession: NZ_CP041729
• Organism: Corynebacterium glutamicum strain JH41

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOY32_RS11690
• Protein ID: WP_080724094.1
• Coordinates: 2479385..2479684 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FOY32_RS11685
• Protein ID: WP_038583360.1
• Coordinates: 2479155..2479388 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOY32_RS11665	2475213..2476424	-	1212	WP_143854799.1	esterase family protein	-
FOY32_RS11670	2476620..2477705	+	1086	WP_038583350.1	redox-regulated ATPase YchF	-
FOY32_RS11675	2477870..2478259	+	390	WP_038583354.1	hypothetical protein	-
FOY32_RS11680	2478448..2478888	+	441	WP_038583357.1	YtoQ family protein	-
FOY32_RS11685	2479155..2479388	+	234	WP_038583360.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FOY32_RS11690	2479385..2479684	+	300	WP_080724094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOY32_RS11695	2479723..2479989	+	267	WP_143855333.1	helix-turn-helix transcriptional regulator	-
FOY32_RS11700	2480207..2480563	-	357	WP_051904590.1	hypothetical protein	-
FOY32_RS11705	2480622..2481134	-	513	WP_143854800.1	hypothetical protein	-
FOY32_RS11710	2481354..2481812	+	459	WP_038583364.1	NUDIX domain-containing protein	-
FOY32_RS11715	2481987..2482082	+	96	Protein_2236	CGNR zinc finger domain-containing protein	-
FOY32_RS11720	2482198..2482734	-	537	WP_051907073.1	hypothetical protein	-
FOY32_RS11725	2482757..2483125	-	369	WP_038583367.1	SMI1/KNR4 family protein	-
FOY32_RS11730	2483243..2483737	+	495	WP_038583369.1	2'-5' RNA ligase	-
FOY32_RS11735	2483834..2484340	+	507	WP_038586898.1	hemerythrin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11462.00 Da
• Isoelectric Point: 10.2383

>T129051 WP_080724094.1 NZ_CP041729:2479385-2479684 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGCSREEIRVGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T129051 NZ_CP041729:2479385-2479684 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCTGTAGTC
GTGAGGAAATTCGCGTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8474.45 Da
• Isoelectric Point: 4.4143

>AT129051 WP_038583360.1 NZ_CP041729:2479155-2479388 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGKMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT129051 NZ_CP041729:2479155-2479388 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAAAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA