Detailed information of TA system TA129050

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1483244..1483773
• Replicon: chromosome
• Accession: NZ_CP041728
• Organism: Corynebacterium glutamicum strain JH41 parent

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOL53_RS07060
• Protein ID: WP_080724094.1
• Coordinates: 1483474..1483773 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FOL53_RS07055
• Protein ID: WP_038583360.1
• Coordinates: 1483244..1483477 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOL53_RS07035	1479302..1480513	-	1212	WP_143854799.1	esterase family protein	-
FOL53_RS07040	1480709..1481794	+	1086	WP_038583350.1	redox-regulated ATPase YchF	-
FOL53_RS07045	1481959..1482348	+	390	WP_038583354.1	hypothetical protein	-
FOL53_RS07050	1482537..1482977	+	441	WP_038583357.1	YtoQ family protein	-
FOL53_RS07055	1483244..1483477	+	234	WP_038583360.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FOL53_RS07060	1483474..1483773	+	300	WP_080724094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOL53_RS07065	1483812..1484078	+	267	WP_143855333.1	helix-turn-helix transcriptional regulator	-
FOL53_RS07070	1484296..1484652	-	357	WP_051904590.1	hypothetical protein	-
FOL53_RS07075	1484711..1485223	-	513	WP_143854800.1	hypothetical protein	-
FOL53_RS07080	1485443..1485901	+	459	WP_038583364.1	NUDIX domain-containing protein	-
FOL53_RS07085	1486076..1486171	+	96	Protein_1356	CGNR zinc finger domain-containing protein	-
FOL53_RS07090	1486287..1486823	-	537	WP_051907073.1	hypothetical protein	-
FOL53_RS07095	1486846..1487214	-	369	WP_038583367.1	SMI1/KNR4 family protein	-
FOL53_RS07100	1487332..1487826	+	495	WP_038583369.1	2'-5' RNA ligase	-
FOL53_RS07105	1487923..1488429	+	507	WP_038586898.1	hemerythrin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11462.00 Da
• Isoelectric Point: 10.2383

>T129050 WP_080724094.1 NZ_CP041728:1483474-1483773 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGCSREEIRVGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T129050 NZ_CP041728:1483474-1483773 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCTGTAGTC
GTGAGGAAATTCGCGTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8474.45 Da
• Isoelectric Point: 4.4143

>AT129050 WP_038583360.1 NZ_CP041728:1483244-1483477 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGKMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT129050 NZ_CP041728:1483244-1483477 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAAAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA