Detailed information of TA system TA129049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 308581..309390
• Replicon: chromosome
• Accession: NZ_CP041727
• Organism: Staphylococcus lugdunensis strain SL122

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: FO459_RS01710
• Protein ID: WP_002458758.1
• Coordinates: 309220..309390 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A853V5R2
• Locus tag: FO459_RS01705
• Protein ID: WP_002458757.1
• Coordinates: 308581..309180 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO459_RS01685	304168..305625	+	1458	WP_002477974.1	ABC transporter substrate-binding protein/permease	-
FO459_RS01690	305618..306343	+	726	WP_002477975.1	amino acid ABC transporter ATP-binding protein	-
FO459_RS01695	306801..307943	+	1143	WP_141760444.1	tRNA epoxyqueuosine(34) reductase QueG	-
FO459_RS01700	307945..308415	+	471	WP_002458756.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
FO459_RS01705	308581..309180	+	600	WP_002458757.1	glucosamine-6-phosphate isomerase	Antitoxin
FO459_RS01710	309220..309390	+	171	WP_002458758.1	hypothetical protein	Toxin
FO459_RS01715	309564..309959	+	396	WP_002458759.1	hypothetical protein	-
FO459_RS01720	310087..311472	+	1386	WP_002477977.1	class II fumarate hydratase	-
FO459_RS01725	311537..312373	-	837	WP_002477978.1	RluA family pseudouridine synthase	-
FO459_RS01730	312541..313653	+	1113	WP_002477979.1	GAF domain-containing sensor histidine kinase	-
FO459_RS01735	313675..314298	+	624	WP_002477980.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (131-195)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6565.10 Da
• Isoelectric Point: 4.6723

>T129049 WP_002458758.1 NZ_CP041727:309220-309390 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Nucleotide

• Length: 171 bp

>T129049 NZ_CP041727:309220-309390 [Staphylococcus lugdunensis]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22619.51 Da
• Isoelectric Point: 4.9539

>AT129049 WP_002458757.1 NZ_CP041727:308581-309180 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLILQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Nucleotide

• Length: 600 bp

>AT129049 NZ_CP041727:308581-309180 [Staphylococcus lugdunensis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAAAGATCAAGTTGCAGAGTATTCAGCAGATATCATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCTGGATTTCATTTAAACAAAGAGGCATCACCAGTACTTGATATGCTTAAAAAGAATGTTG
ACCAACATGCGGTTGACTTCAGCCAAATTAACATTCTTGACTATGATCAAAATCAAGAATATTTCAAAGCGCTGGGGGTT
CCTGAGAGTCAAATTTATCCTATCTCATACGATCAAGATGCTGAAGCGTTTATCTCTGATAAAATCAAAACAAAAGATAA
TAAAGGGAAACTAATATTACAAGTAGCTTCAATTGATGATCAAGGAAACCTTAATATCAGTCTACGTCAAGGATTGTTAA
ATGCTAGAGAAATTATCTTAGTCATTACAGGACATAATAAAAAAGAAGTAGTAGAAAAACTGTATAATGAAAATGGAAAA
TCTAATTTTGAACCTGCTGATTTAAAAGCACATCGTATGGTAACGGTTATTTTAGACGAAGCGGCAGCTGAAGGTTTGCC
AGAAGATGTACGTCATTACTTTACTGATCGGTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A853V5R2