Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 168612..169129 Replicon chromosome
Accession NZ_CP041727
Organism Staphylococcus lugdunensis strain SL122

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag FO459_RS00915 Protein ID WP_002461192.1
Coordinates 168779..169129 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag FO459_RS00910 Protein ID WP_002461193.1
Coordinates 168612..168782 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO459_RS00885 164437..164919 + 483 WP_002478975.1 PH domain-containing protein -
FO459_RS00890 164912..166426 + 1515 WP_002461198.1 PH domain-containing protein -
FO459_RS00895 166413..166925 + 513 WP_002478976.1 PH domain-containing protein -
FO459_RS00900 166937..167329 + 393 WP_002461196.1 holo-ACP synthase -
FO459_RS00905 167377..168525 + 1149 WP_002478977.1 alanine racemase -
FO459_RS00910 168612..168782 + 171 WP_002461193.1 hypothetical protein Antitoxin
FO459_RS00915 168779..169129 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FO459_RS00920 169563..170564 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
FO459_RS00925 170655..170981 + 327 WP_002461190.1 anti-sigma factor antagonist -
FO459_RS00930 170983..171462 + 480 WP_002478979.1 anti-sigma B factor RsbW -
FO459_RS00935 171437..172207 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T129048 WP_002461192.1 NZ_CP041727:168779-169129 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T129048 NZ_CP041727:168779-169129 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
CATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGCTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT129048 WP_002461193.1 NZ_CP041727:168612-168782 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT129048 NZ_CP041727:168612-168782 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTCCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References