Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 705512..706321 Replicon chromosome
Accession NZ_CP041726
Organism Staphylococcus lugdunensis strain SL118

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag FO458_RS03575 Protein ID WP_002458758.1
Coordinates 706151..706321 (+) Length 57 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag FO458_RS03570 Protein ID WP_070648686.1
Coordinates 705512..706111 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO458_RS03550 701099..702556 + 1458 WP_002477974.1 ABC transporter substrate-binding protein/permease -
FO458_RS03555 702549..703274 + 726 WP_070648683.1 amino acid ABC transporter ATP-binding protein -
FO458_RS03560 703732..704874 + 1143 WP_141758337.1 tRNA epoxyqueuosine(34) reductase QueG -
FO458_RS03565 704876..705346 + 471 WP_150908350.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
FO458_RS03570 705512..706111 + 600 WP_070648686.1 glucosamine-6-phosphate isomerase Antitoxin
FO458_RS03575 706151..706321 + 171 WP_002458758.1 hypothetical protein Toxin
FO458_RS03580 706495..706890 + 396 WP_002458759.1 hypothetical protein -
FO458_RS03585 707018..708403 + 1386 WP_070648688.1 class II fumarate hydratase -
FO458_RS03590 708468..709304 - 837 WP_002477978.1 RluA family pseudouridine synthase -
FO458_RS03595 709472..710584 + 1113 WP_060795476.1 GAF domain-containing sensor histidine kinase -
FO458_RS03600 710606..711229 + 624 WP_002477980.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(131-195)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6565.10 Da        Isoelectric Point: 4.6723

>T129046 WP_002458758.1 NZ_CP041726:706151-706321 [Staphylococcus lugdunensis]
MSKEKKSRLNYHEEENAMVENLEDLKELGKEMEHISEKNDEEKVNQSHDTSKSSNS

Download         Length: 171 bp

>T129046 NZ_CP041726:706151-706321 [Staphylococcus lugdunensis]
ATGTCAAAAGAAAAAAAGAGTCGTTTAAATTATCATGAGGAAGAGAATGCGATGGTTGAAAATTTAGAAGACTTAAAAGA
GCTGGGCAAAGAAATGGAACACATCTCAGAGAAAAATGACGAAGAAAAAGTTAATCAATCGCATGATACATCAAAGTCTT
CAAATTCATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22637.55 Da        Isoelectric Point: 4.9539

>AT129046 WP_070648686.1 NZ_CP041726:705512-706111 [Staphylococcus lugdunensis]
MAMNFKVFENKDQVAEYSADIIRKQFNNNPTTIAGFHLNKEASPVLDMLKKNVDQHAVDFSQINILDYDQNQEYFKALGV
PESQIYPISYDQDAEAFISDKIKTKDNKGKLMLQVASIDDQGNLNISLRQGLLNAREIILVITGHNKKEVVEKLYNENGK
SNFEPADLKAHRMVTVILDEAAAEGLPEDVRHYFTDRFA

Download         Length: 600 bp

>AT129046 NZ_CP041726:705512-706111 [Staphylococcus lugdunensis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAAAGATCAAGTTGCAGAGTATTCAGCAGATATCATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCTGGATTTCATTTAAACAAAGAGGCATCACCAGTACTTGATATGCTTAAAAAGAATGTTG
ACCAACATGCGGTTGACTTCAGCCAAATTAACATTCTTGACTATGATCAAAATCAAGAATATTTCAAAGCGCTGGGGGTT
CCTGAGAGTCAAATTTATCCTATCTCATACGATCAAGATGCTGAAGCGTTTATCTCTGATAAAATCAAAACAAAAGATAA
TAAAGGGAAACTAATGTTACAAGTAGCTTCAATTGATGATCAAGGAAACCTTAATATCAGTCTACGTCAAGGATTGTTAA
ATGCTAGAGAAATTATCTTAGTCATTACAGGACATAATAAAAAAGAAGTAGTAGAAAAACTGTATAATGAAAATGGAAAA
TCTAATTTTGAACCTGCTGATTTAAAAGCACATCGTATGGTAACGGTTATTTTAGACGAAGCGGCAGCTGAAGGTTTGCC
AGAAGATGTACGTCATTACTTTACTGATCGGTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References