Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 549147..549664 Replicon chromosome
Accession NZ_CP041726
Organism Staphylococcus lugdunensis strain SL118

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag FO458_RS02665 Protein ID WP_002461192.1
Coordinates 549314..549664 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag FO458_RS02660 Protein ID WP_002461193.1
Coordinates 549147..549317 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO458_RS02635 544972..545454 + 483 WP_002492078.1 PH domain-containing protein -
FO458_RS02640 545447..546961 + 1515 WP_070647976.1 PH domain-containing protein -
FO458_RS02645 546948..547460 + 513 WP_002478976.1 PH domain-containing protein -
FO458_RS02650 547472..547864 + 393 WP_002461196.1 holo-ACP synthase -
FO458_RS02655 547912..549060 + 1149 WP_070647975.1 alanine racemase -
FO458_RS02660 549147..549317 + 171 WP_002461193.1 hypothetical protein Antitoxin
FO458_RS02665 549314..549664 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FO458_RS02670 550098..551099 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
FO458_RS02675 551190..551516 + 327 WP_070647974.1 anti-sigma factor antagonist -
FO458_RS02680 551518..551997 + 480 WP_012990787.1 anti-sigma B factor RsbW -
FO458_RS02685 551972..552742 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T129045 WP_002461192.1 NZ_CP041726:549314-549664 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T129045 NZ_CP041726:549314-549664 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
CATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT129045 WP_002461193.1 NZ_CP041726:549147-549317 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT129045 NZ_CP041726:549147-549317 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References