Detailed information of TA system TA129043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 2162195..2162985
• Replicon: chromosome
• Accession: NZ_CP041725
• Organism: Staphylococcus lugdunensis strain SL117

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FO457_RS10525
• Protein ID: WP_150907598.1
• Coordinates: 2162521..2162985 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FO457_RS10520
• Protein ID: WP_012991010.1
• Coordinates: 2162195..2162509 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FO457_RS10480	2157863..2158303	-	441	WP_012991001.1	single-stranded DNA-binding protein	-
FO457_RS10485	2158300..2158974	-	675	WP_012991002.1	ERF family protein	-
FO457_RS10490	2158975..2159460	-	486	WP_012991003.1	siphovirus Gp157 family protein	-
FO457_RS10495	2159529..2159708	-	180	WP_041612466.1	hypothetical protein	-
FO457_RS10500	2159936..2160538	+	603	WP_012991005.1	hypothetical protein	-
FO457_RS10505	2160584..2161336	-	753	WP_012991006.1	phage antirepressor KilAC domain-containing protein	-
FO457_RS10510	2161344..2161637	+	294	WP_049823122.1	hypothetical protein	-
FO457_RS12885	2161630..2161791	-	162	WP_012991008.1	hypothetical protein	-
FO457_RS10515	2161807..2162043	-	237	WP_012991009.1	helix-turn-helix domain-containing protein	-
FO457_RS10520	2162195..2162509	+	315	WP_012991010.1	helix-turn-helix domain-containing protein	Antitoxin
FO457_RS10525	2162521..2162985	+	465	WP_150907598.1	ImmA/IrrE family metallo-endopeptidase	Toxin
FO457_RS12890	2163033..2163176	+	144	WP_012991012.1	hypothetical protein	-
FO457_RS10530	2163309..2163491	+	183	WP_012991013.1	hypothetical protein	-
FO457_RS10535	2163645..2164685	+	1041	WP_150907600.1	Abi family protein	-
FO457_RS10540	2164754..2166136	+	1383	WP_012991015.1	recombinase family protein	-
FO457_RS10545	2166166..2167356	+	1191	Protein_2034	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2124240..2166136	41896

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (15-118)

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 18370.95 Da
• Isoelectric Point: 6.4988

>T129043 WP_150907598.1 NZ_CP041725:2162521-2162985 [Staphylococcus lugdunensis]
MGLYEKILIEHDYIEVRETDVMPNDLHGLWLGDLILIKRNLPETRKAEVLYEELAHHKLTYGNILDQSKWINRKFENYAK
RHGYEAALPLRIIVEAHHYGVSNLYELAQYVQLSEEHVLEILEHYKQKHGIGTHYGDYSITFEPLRVYKLHRFD

Nucleotide

• Length: 465 bp

>T129043 NZ_CP041725:2162521-2162985 [Staphylococcus lugdunensis]
ATGGGGTTATATGAAAAAATTTTAATAGAGCATGACTATATAGAAGTTAGAGAAACAGATGTTATGCCTAATGACTTACA
CGGTTTATGGTTAGGTGATTTAATTCTAATTAAACGCAACCTACCCGAAACGCGCAAAGCCGAAGTTCTCTACGAAGAAT
TAGCACATCATAAACTTACATATGGGAATATCTTAGACCAGTCTAAATGGATTAACCGTAAATTCGAAAACTACGCTAAA
CGTCACGGATACGAGGCAGCACTGCCTTTGCGTATTATCGTTGAGGCACATCATTACGGTGTAAGTAACTTATACGAACT
AGCACAGTATGTTCAATTAAGTGAAGAACATGTATTAGAAATATTGGAACATTACAAACAGAAACATGGTATTGGAACTC
ACTACGGCGATTACTCAATTACGTTTGAGCCGTTGAGAGTGTACAAATTGCATAGATTTGATTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12073.64 Da
• Isoelectric Point: 7.1672

>AT129043 WP_012991010.1 NZ_CP041725:2162195-2162509 [Staphylococcus lugdunensis]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIEETDEQPQHRAAHL
EGELTDEEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT129043 NZ_CP041725:2162195-2162509 [Staphylococcus lugdunensis]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTAGCTGAACTAGGAAGAAAAATCGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGTGGAAATATCAAAAATCTTAAAAACGATACTATCGAAAGCATAGCTACGG
CATTAAATGTTAACCCTGCATTTTTGATGGGTTGGATAGAAGAAACTGATGAACAACCACAACATCGTGCAGCACATCTT
GAAGGGGAATTAACAGATGAAGAATGGCAACGCGTTCTAGATTATGCAGATTATATAAGAAGCAAACGTAAATAA